APPLICATIONS OF TECHNOLOGY: Plant genome editing (e.g. targeted gene insertion) BENEFITS: This invention provides targeted gene insertion at pre-determined genomic safe harbors in plants at a much higher frequency than current methods. This provides a desirable alternative to random transgene insertion obtained through conventional methods. Obviation of the need … [Read more...] about Marker-free Gene Insertion in Plants via CRISPR-Cas9 2019-055
Biotechnology and Medicine
New Synthetic Transcription Factors and Promoters to Modulate Transgene Expression Strength 2019-100
APPLICATIONS: Agriculture Controlling gene expression in plants Modifying plants traits for the efficient production of food and other bio-based products BENEFITS: Creates a contributing effect of specific genetic elements in controlling gene expression Improvements in controlling and tuning gene expression Maximizes sequence diversity while tuning … [Read more...] about New Synthetic Transcription Factors and Promoters to Modulate Transgene Expression Strength 2019-100
A System for Homogenous Editing of Mitochondrial Chromosomes 2017-153
APPLICATIONS OF TECHNOLOGY: Industrial biotechnology DNA mutation repair Genetics in organelles ADVANTAGES: Efficient, homoplasmic integrations in the mitochondrial genome Genetic change of the mtDNA without a selection marker BACKGROUND: Targeted genome engineering for mitochondria and other organelles has important implications in fungal, plant, … [Read more...] about A System for Homogenous Editing of Mitochondrial Chromosomes 2017-153
Novel Methods for the Barcoding of Bacteriophages 2019-113
APPLICATIONS OF TECHNOLOGY: Phage engineering Cataloging and Control of phages Diagnosis and Antibiotic Discovery ADVANTAGES: No interference of the phage infection cycle No compromise of the host bacteria life cycle Enables easy amplification of the DNA “barcode” for identification, tracking and control of individual phages Standardizes the workflow … [Read more...] about Novel Methods for the Barcoding of Bacteriophages 2019-113
Gut Microbiome Engineering for the Heterologous Production of Antiviral Compounds 2019-085
APPLICATIONS OF TECHNOLOGY: Medical: Pharmaceuticals ADVANTAGES: Present strain is among the most robust constituents of the gut microbiome Obviates the need for exogenous iron-sulfur cluster producing genetic elements ABSTRACT: In 2018, Gizzi et al. demonstrated that the human gene Viperin can produce antiviral small molecules (ddhCTP) that act as a chain … [Read more...] about Gut Microbiome Engineering for the Heterologous Production of Antiviral Compounds 2019-085
