APPLICATIONS OF TECHNOLOGY: Production of oxidized terpenes and of terpene-based bioproducts (e.g. fuel additives, fragrances, insecticides, pharmaceuticals) BENEFITS: Enables more efficient production of functionalized terpenes BACKGROUND: The functionalization of terpene hydrocarbons using cytochrome P450 enzymes could derive many useful compounds that … [Read more...] about Efficient Production of Oxidized Terpenes Via Enzyme Fusion Strategy 2019-108
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New Synthetic Transcription Factors and Promoters to Modulate Transgene Expression Strength 2019-100
APPLICATIONS: Agriculture Controlling gene expression in plants Modifying plants traits for the efficient production of food and other bio-based products BENEFITS: Creates a contributing effect of specific genetic elements in controlling gene expression Improvements in controlling and tuning gene expression Maximizes sequence diversity while tuning … [Read more...] about New Synthetic Transcription Factors and Promoters to Modulate Transgene Expression Strength 2019-100
A System for Homogenous Editing of Mitochondrial Chromosomes 2017-153
APPLICATIONS OF TECHNOLOGY: Industrial biotechnology DNA mutation repair Genetics in organelles ADVANTAGES: Efficient, homoplasmic integrations in the mitochondrial genome Genetic change of the mtDNA without a selection marker BACKGROUND: Targeted genome engineering for mitochondria and other organelles has important implications in fungal, plant, … [Read more...] about A System for Homogenous Editing of Mitochondrial Chromosomes 2017-153
High Production Titers and Rates of Tetramethyl Pyrazine 2018-101
APPLICATIONS OF TECHNOLOGY: Food (coffee) flavoring Polymer/ resin component ADVANTAGES: While Corynebacterium glutamicum has been previously reported to produce alkyl pyrazines in mixture at low levels over a long cultivation period, the high production titers and rates of enriched tetramethyl pyrazine in glutamicum in … [Read more...] about High Production Titers and Rates of Tetramethyl Pyrazine 2018-101
A CRISPR-Based and Metabolic Modeling Guided Strategy to Maximizing Indigoidine Production 2019-145
APPLICATIONS OF TECHNOLOGY: Dye and pigment (food, clothing, consumer goods) BACKGROUND: Indigodine is a natural blue pigment that retains its brightness and has direct uses in the dye and pigment industry. Notably, it shows promise as an alternative to synthetic dyes and in providing health benefits as an antioxidant … [Read more...] about A CRISPR-Based and Metabolic Modeling Guided Strategy to Maximizing Indigoidine Production 2019-145