Novel Fluidic System for Accurate High Speed Atomic Force Microscopy (AFM) and Confocal/Super Resolution Systems 2021-020

This invention provides improved timing and concentration precision compared to current fluidic exchange designs. This tool is ideal for those conducting microscopy-based studies of reaction kinetics. Inventor: Paul Ashby. Contact: Sebastian Ainslie, SAinslie@lbl.gov

Spectroscopic Imaging and Analysis of Live Cells 2015-077

This invention is a tool for the measurement, visualization, and analysis of chemical dynamics in living cells or tissues for diagnostic pathology. Inventors: Keven Loutherback, Hoi-Ying Holman.

Contact: Jeremy Greeter, jgreeter@lbl.gov

Gold Nanoparticle Film for Nanostructure-Initiator Mass Spectrometry (NIMS) 2017-036

This invention can detect small molecules, peptides, lipids, and enzyme activity. This tool can predictably fractionate complex samples to simplify the assay process for diagnostics, manufacturing, and pharmaceutical processes. Inventors: Todd Duncombe, Trent Northen.

Contact: Robin Johnston, RJohnston@lbl.gov

Contactless Loading to a Microfluidic Chip 2019-078

This invention minimizes waste, reduces cost, and streamlines loading of samples by size-matching the dispensed droplets to the microfluidic channels. Those looking for high throughput sample introduction for genomic and sequencing sample preparation and analysis will find this tool particularly useful. Inventors: Kosuke Iwai, William Gailard. Contact: Robin Johnston, RJohnston@lbl.gov

Parallel Droplet Manipulation and Digital Microfluidic Droplet Generation, Transport, Splitting, and Merging 2017-053

This invention enhances and streamlines drop manipulation, improves chip capabilities, and reduces manufacturing costs for increased experimental flexibility in synthetic biology and biological assay applications.  Inventors: Philip Gach, Anup Singh. Contact: Robin Johnston, rjohnston@lbl.gov

MicroNIMS for Enzyme Assay 2016-049

This invention can array large quantities of enzymes and substrate onto a defined grid to allow enzymatic characterization in addition to quantifying small molecule biomarkers from different biofluids. This tool addresses traditional incompatibilities between droplet and digital microfluidics and mass spectrometry-based detection. Inventors: Joshua Heinemann, Trent Northen. Contact: Robin Johnston, RJohnston@lbl.gov

Determining Ligninases Activities through Nanostructure Initiator Mass Spectrometry 

(NIMS) 2016-109

This invention combines substrates for cellulase, hemicellulases and ligninases in a high throughput screening method to create assays that can simultaneously detect several enzyme activities. This is especially useful for capturing unknown or unexpected enzyme activities in cell cultures and environmental samples. Inventors: Kai Deng, Trent Northen. Contact: Robin Johnston, RJohnston@lbl.gov