APPLICATION OF TECHNOLOGY: Atomic Force Microscopy (AFM) characterization of materials in a liquid environment ADVANTAGE: Mitigates water condensation issues in an earlier design for improved performance ABSTRACT: A low damping force sensor for operation in liquid, intended for use with atomic force microscopes (AFMs) or other mechanical sensors in liquid, … [Read more...] about Sensor for Low-Noise Force Detection in Liquids 2017-184
Microscopy / Spectroscopy
Optical-Cavity Phase Plate for Controllable, Stable Phase Shift in TEM and Cryo-EM Applications 2017-080
APPLICATIONS OF TECHNOLOGY: Biological research using high resolution cryogenic electron microscopy (cryo-EM) Hard-matter material characterization Other forms of research using transmission electron microscopy (TEM) ADVANTAGES: Ensures data of equally high quality for entire data collection period Equally useful for radiation-tolerant and … [Read more...] about Optical-Cavity Phase Plate for Controllable, Stable Phase Shift in TEM and Cryo-EM Applications 2017-080
Matched Illumination and Detector Interferometry Scanning Transmission Electron Microscopy (MIDI-STEM) for Efficient Phase-Contrast Imaging 2015-170
APPLICATIONS OF TECHNOLOGY: Analyzing material interfaces Imaging classes of materials that are challenging to image conventionally ADVANTAGES: High signal efficiency Good transfer of low spatial frequency information Enables imaging while in-focus to minimize signal delocalization Anticipated to enable complete aberration correction Adaptable to … [Read more...] about Matched Illumination and Detector Interferometry Scanning Transmission Electron Microscopy (MIDI-STEM) for Efficient Phase-Contrast Imaging 2015-170
Consistent, Reliable Preparation of Cryo-EM Specimens 2015-108
APPLICATIONS: Preparation of biological samples for electron microscopy ADVANTAGES: Enables consistent and reliable production of samples Thickness of cryo-EM specimens is uniform across the grid Facilitates the production of extremely thin samples Potentially damaging sample evaporation not required ABSTRACT: Researchers at Berkeley Lab have … [Read more...] about Consistent, Reliable Preparation of Cryo-EM Specimens 2015-108
High-Affinity Specimen Support Film for Electron Microscopy 2015-002
APPLICATIONS: Sample preparation for electron microscopy of biological macromolecules ADVANTAGES: Protective, soluble coating ensures long shelf life, enabling commercial distribution Employs streptavidin monolayer-crystals for a combination of high affinity and specificity when binding macromolecules Affinity binding to the substrate prevents unwanted … [Read more...] about High-Affinity Specimen Support Film for Electron Microscopy 2015-002