APPLICATIONS OF TECHNOLOGY: • Point-of-care clinical diagnostics • Remote sensing of hazardous materials • Toxic gas leak detection • Physical incorporation into cell phones or small devices for remote detection, e.g., drones ADVANTAGES: • High specificity in analyte identification • Small in size for field portability • Low power requirement and cost • … [Read more...] about PUMA: Ultrasensitive Detection of Biological and Chemical Agents 2017-054
Research Tools
Spectroscopic Imaging and Analysis of Live Cells 2015-077
ABSTRACT: Researchers at Berkeley Lab led by Hoi-Ying Holman have developed technologies for measurement, visualization, and analysis of chemical dynamics in living cells or tissues for diagnostic pathology. Devices can be open- or closed-channel microfluidic membrane devices for long-term IR spectroscopy of live adherent cells and ultimately for rapidly identifying … [Read more...] about Spectroscopic Imaging and Analysis of Live Cells 2015-077
ANIcalculator (Average Nucleotide Identity Calculator) 2014-127
APPLICATIONS OF TECHNOLOGY: Genome sequencing ABSTRACT: Increased sequencing of microbial genomes has revealed that prevailing prokaryotic species assignments can be inconsistent with whole genome information for a significant number of species. The long-standing need for a systematic and scalable species assignment technique can be met by the genome-wide Average … [Read more...] about ANIcalculator (Average Nucleotide Identity Calculator) 2014-127
Thermostable RNA-Guided Endonucleases (GEOCAS9) 2017-117
APPLICATIONS OF TECHNOLOGY: Genome editing Genetic engineering Gene therapy Research tools (e.g., high-throughput screening of gene functions in cell lines and in vivo) Creation of transgenic animal models ADVANTAGES: Functions under different conditions than current CRISPR-Cas9 proteins (e.g, thermostable and enzymatically active in a wide temperature … [Read more...] about Thermostable RNA-Guided Endonucleases (GEOCAS9) 2017-117
Optical-Cavity Phase Plate for Controllable, Stable Phase Shift in TEM and Cryo-EM Applications 2017-080
APPLICATIONS OF TECHNOLOGY: Biological research using high resolution cryogenic electron microscopy (cryo-EM) Hard-matter material characterization Other forms of research using transmission electron microscopy (TEM) ADVANTAGES: Ensures data of equally high quality for entire data collection period Equally useful for radiation-tolerant and … [Read more...] about Optical-Cavity Phase Plate for Controllable, Stable Phase Shift in TEM and Cryo-EM Applications 2017-080