APPLICATIONS OF TECHNOLOGY: Purification of five different His-tagged proteins expressed in E. coli using the Berkeley Lab His-tag aptamer magnetic beads (1a-5a) or commercially available … [Read more...] about Aptamer for the Histidine Tag and an Improved Method for the Generation of High Affinity Aptamers IB-1929
Research Tools
Biomarker for Cell Senescence IB-1036
E.O. Lawrence Berkeley National Laboratory APPLICATIONS OF TECHNOLOGY: Screen compounds for effects on cell senescence, including high throughput applications Pre and post surgical tissue assay Cancer and aging research ADVANTAGES: This method provides a rapid, convenient and inexpensive basis to: Screen biological or pharmaceutical compounds that have … [Read more...] about Biomarker for Cell Senescence IB-1036
MEA Chips for Integrated Microscopic Imaging and Liquid Chromatography Mass Spectrometry IB-3303
APPLICATIONS OF TECHNOLOGY: In-vitro diagnostics Electrospray ionization mass spectrometry (ESI-MS), chromatography, microscopy, single cell omics, microfluidics Biopharmaceutical R & D Lab-on-a-chip analysis Environmental monitoring ADVANTAGES: Integrated on-chip imaging and liquid chromatography functions Robust and scalable silicon … [Read more...] about MEA Chips for Integrated Microscopic Imaging and Liquid Chromatography Mass Spectrometry IB-3303
Highly Stable 15nm Micelles for Drug Delivery and other Biomedical Applications JIB-2813, JIB-3230
APPLICATIONS OF TECHNOLOGY: Targeted drug delivery Gene therapy Vaccine development Imaging agents Cancer research ADVANTAGES: Long lasting – in vivo half-life 29.5 hours Tunable size and stability provide platform for drug formulation Low “cargo” leakage Deep penetration in tumor tissues – micelles in ~ 15nm range Self-assembling Efficient … [Read more...] about Highly Stable 15nm Micelles for Drug Delivery and other Biomedical Applications JIB-2813, JIB-3230
Efficient, Reproducible Immortalization of Normal Human Mammary Epithelial Cells (HMECs) Using Pathologically Relevant Agents JIB- 2013-168
APPLICATIONS OF TECHNOLOGY: Testing potential therapeutics to prevent cancer progression to immortality and malignancy reverse immortalization in cancer cells Assays to identify agents that promote immortalization and malignancy Generation of immortal and malignant lines from any individual’s normal HMEC ADVANTAGES: Unique technology using … [Read more...] about Efficient, Reproducible Immortalization of Normal Human Mammary Epithelial Cells (HMECs) Using Pathologically Relevant Agents JIB- 2013-168