APPLICATIONS OF TECHNOLOGY: Treatment of breast and other cancers ADVANTAGES: Targets cancer cells only; does not damage normal cells Enhanced efficacy in the most aggressive breast tumors No known side effects Potential expansion to other solid tumor types ABSTRACT: Mina Bissell and colleagues at Berkeley Lab have identified and isolated several … [Read more...] about Native Cytokines for the Treatment of Advanced Breast Cancer and Other Tumors JIB-2718
Detecting and Treating Breast Cancer Resistance to EGFR Inhibitors IB-2578
ABSTRACT: Mina Bissell and colleagues at Berkeley Lab have developed therapeutic compositions and methods related to inhibition of FAM83A as well as methods of diagnosing cancer resistance to EGFR inhibitors. For details, see the issued U. S. Patent #9,303,088, available at www.uspto.gov. FOR MORE … [Read more...] about Detecting and Treating Breast Cancer Resistance to EGFR Inhibitors IB-2578
Acid-Degradeable and Bioerodible Materials JIB-2595
APPLICATIONS OF TECHNOLOGY: Drug delivery, including controlled-release formulations Vaccine and immunotherapy Gene therapy Chemotherapy Sutures, scaffolds, and implantable bulk materials Diagnosis and imaging ADVANTAGES: Site-specific delivery, accurate therapeutic targeting Payload release or degradation rate can be tuned easily—from minutes to hours to … [Read more...] about Acid-Degradeable and Bioerodible Materials JIB-2595
Identifying Biomarkers of Physiological Responses of Cancer Cells IB-2546
APPLICATIONS OF TECHNOLOGY: Personalized cancer treatment Clinical trials Development of secondary therapeutic combinations ADVANTAGES: Identifies molecular markers with greater specificity Distinctly models diverse drug response patterns Improves clinical outcomes Applies to multiple organ-specific cancers (breast, colon, pancreatic, ovarian, … [Read more...] about Identifying Biomarkers of Physiological Responses of Cancer Cells IB-2546
High Selectivity Peptides for Cancer Therapy, Screening for Cancer Therapies, and Therapy Sensitization IB-2489
APPLICATIONS OF TECHNOLOGY: High-throughput screening for therapeutics that synergize with TIN2 complex disruption Sensitizing cancer cells to other therapeutic agents Therapy for multiple types of cancer exhibiting p53-negative cancer cells ADVANTAGES: Targets a subset of aggressive cancer cells by using TIN2-complex binding peptides Could be combined … [Read more...] about High Selectivity Peptides for Cancer Therapy, Screening for Cancer Therapies, and Therapy Sensitization IB-2489