APPLICATIONS OF TECHNOLOGY: Testing potential therapeutics to prevent cancer progression to immortality and malignancy reverse immortalization in cancer cells Assays to identify agents that promote immortalization and malignancy Generation of immortal and malignant lines from any individual’s normal HMEC ADVANTAGES: Unique technology using … [Read more...] about Efficient, Reproducible Immortalization of Normal Human Mammary Epithelial Cells (HMECs) Using Pathologically Relevant Agents JIB- 2013-168
Classification of Tumor Composition and Delineation of Cellular Regions via Dictionary and Sparse Coding IB- 2013-173
APPLICATIONS OF TECHNOLOGY: Digital histopathology Precision medicine in oncology Oncology drug development and R&D ADVANTAGES: Impervious to biological and technical batch variation Quantifies tumor composition via cell-by-cell profiling Measures cellular processes such as mitosis Extensible to a variety of other tumor types ABSTRACT: Berkeley … [Read more...] about Classification of Tumor Composition and Delineation of Cellular Regions via Dictionary and Sparse Coding IB- 2013-173
Remineralization and Repair of Calcified Tissues using Biomimetic Polymer 2013-056
APPLICATIONS OF TECHNOLOGY: Preventive dentistry, e.g., toothpaste additive Regenerative, implant and cosmetic dentistry Periodontics and oral surgery Orthopedics Industrial processes requiring crystallization or amorphous precipitation ADVANTAGES: Minimally invasive route to restoring tooth structure Reduces dental health costs Biomimetic … [Read more...] about Remineralization and Repair of Calcified Tissues using Biomimetic Polymer 2013-056
Breast Cancer Therapy and Potential Method for Enhancing Radiation Sensitivity via Inhibition of ß1 Integrin IB-1965
APPLICATIONS: Anti-tumor therapy Shows promise for increasing the radiation sensitivity of breast cancer cells ADVANTAGES: In vivo studies have demonstrated the effectiveness of ß1 integrin antibody for anti-tumor therapy In vitro studies show enhancement of radiation sensitivity The tissue environment responds to cancer in a consistent manner, providing a … [Read more...] about Breast Cancer Therapy and Potential Method for Enhancing Radiation Sensitivity via Inhibition of ß1 Integrin IB-1965
Synthetic Nano-Low Density Lipoprotein As a Targeted Drug Delivery Vehicle IB-1931
APPLICATIONS OF TECHNOLOGY: Natural LDL Berkeley Lab's Synthetic nLDL Drug delivery to tumors with increased LDL-cholesterol requirements and LDL receptor activity, including: brain, colon, prostrate, liver, lung, adrenal, hormone unresponsive breast, leukemia ADVANTAGES: Targets the LDL receptor for selective drug delivery and entry … [Read more...] about Synthetic Nano-Low Density Lipoprotein As a Targeted Drug Delivery Vehicle IB-1931