APPLICATIONS OF TECHNOLOGY: Production of Isoprenoid-based biofuels Pharmaceuticals Neutraceuticals Flavors and fragrances Rubber (isoprene) ADVANTAGES: Improves isoprenoid production rates Conserves metabolic materials (carbon) and energy Significantly higher pathway theoretical yield compared to wild type DXP pathway (particularly using feedstocks … [Read more...] about Production of 1-deoxyxylulose-5-phosphate (DXP) EIO-3006
Bio-based products
Microbial Synthesis of Hydroxytyrosol and Other Aromatic Amino Acid Derivatives EJIB-2939
APPLICATIONS OF TECHNOLOGY: Microbial production of Antioxidants, e.g., hydroxytyrosol Supplements, e.g., melatonin Medications, e.g., L-DOPA ADVANTAGES: Inexpensive, consistent production with minimal impurities Independent of olive crop production and expensive chemical synthesis that produces toxic waste Modifiable to produce desired substances … [Read more...] about Microbial Synthesis of Hydroxytyrosol and Other Aromatic Amino Acid Derivatives EJIB-2939
Biological Production of Cinnamoyl Anthranilates EIB-2923
APPLICATIONS OF TECHNOLOGY: Pharmaceutical / nutraceutical industry: antioxidants, antihistamines, wound healing / antifibrotic medicines Life sciences research: pharmaceutical, cosmeceuticals and food additive products such as avenanthramides and Tranilast Chemical production ADVANTAGES: Ecological and nontoxic Potentially less expensive than other … [Read more...] about Biological Production of Cinnamoyl Anthranilates EIB-2923
JBEI Polyketide Synthases Portfolio for Production of Chemicals and Fuels EJIB-2820, EJIB-2825, EIB-2878, EJIB-2982, EJIB-3014
APPLICATIONS OF TECHNOLOGY: Production of the following from sugar or starch: Dicarboxylic acids Diacids Biotin Precursors to isooctane ADVANTAGES: Sustainable replacement for products currently derived from petroleum Flexibility to achieve material properties not otherwise possible Lower production costs ABSTRACT: Researchers at the Joint … [Read more...] about JBEI Polyketide Synthases Portfolio for Production of Chemicals and Fuels EJIB-2820, EJIB-2825, EIB-2878, EJIB-2982, EJIB-3014
Introduction of a Synthetic CO2-fixing Photorespiratory Bypass into a Cyanobacterium 2013-020
ABSTRACT: Global photosynthetic productivity is limited by the enzymatic assimilation of CO2 into organic carbon compounds. Ribulose-1,5- bisphosphate carboxylase/oxygenase (RuBisCO), the carboxylating enzyme of the Calvin-Benson (CB) cycle, poorly discriminates between CO2 and O2, leading to photorespiration and the loss of fixed carbon and nitrogen. With the advent of … [Read more...] about Introduction of a Synthetic CO2-fixing Photorespiratory Bypass into a Cyanobacterium 2013-020