APPLICATIONS OF TECHNOLOGY: High-value products using methylmalonyl-CoA as substrate: Erythromycin (antibiotic) and spinosyn (insecticide) Germicidin, which has significant inhibitory activity on hexokinase which is expressed at a high level in cancer cells Novel recyclable materials Flavors and fragrances Commodity or specialty chemicals ADVANTAGES: … [Read more...] about Genetically Modified Host Cells for Improved Polyketide Production 2022-152
Bio-based products
Metabolic engineering of Issatchenkia orientalis for citramalate production used in PMMA Acrylic Glass 2023-056
APPLICATIONS OF TECHNOLOGY: Production of citramalate, a precursor for polymethyl methacrylate (PMMA) polymers. PMMA is used in electronic device screens, automotive plastics, glazing, building piping, and insulation ADVANTAGES: Increases the achievable carbon yields of select organic acids Consumes less energy and generates less toxic waste than current … [Read more...] about Metabolic engineering of Issatchenkia orientalis for citramalate production used in PMMA Acrylic Glass 2023-056
Expression Platform for Soluble Hydrogenase Production via Escherichia coli 2022-146
APPLICATIONS OF TECHNOLOGY: Renewable hydrocarbon production for biofuels such as biodiesel and ethanol E. coli that can use or produce H2 with its cellular processes, meaning H2 can now be used as a feedstock for biosynthesis. ADVANTAGES: Simplified and efficient expression system compared to traditional methods that use engineered Cupriavidus necator H16 … [Read more...] about Expression Platform for Soluble Hydrogenase Production via Escherichia coli 2022-146
Metabolically Engineered Pseudomonas putida for the Bioproduction of Shinorine, a Natural Sunscreen 2021-119
APPLICATIONS OF TECHNOLOGY: Sunscreen cream ADVANTAGES: Environmentally-friendly sunscreen compound High product titer and yield Fast-growing microbe host Eliminates the use of agricultural plants as feedstocks for Shinorine production BACKGROUND: Compounds such as Oxybenzone, Zinc Oxide (ZnO), and Titanium Dioxide, (TiO2) are ubiquitous in many … [Read more...] about Metabolically Engineered Pseudomonas putida for the Bioproduction of Shinorine, a Natural Sunscreen 2021-119
Materials Technologies
Strong, Long-Range, Aligned Lamellar Structures for Biomedical (Synthetic Bone) and Energy Applications 2015-018 This invention addresses traditional freeze casting issues by creating a second temperature gradient to align the freeze fronts and produce lamellar sheets with long-range orientation. Applications include a wide range of composite materials such as Synthetic … [Read more...] about Materials Technologies