APPLICATIONS OF TECHNOLOGY: Biocatalyst for existing methane conversion technologies Polyester textiles and apparels, automobile coatings, polymers, flavors, fragrances, and vitamin synthesis ADVANTAGES: Reduces reliance on petrochemical-based malonate production Methane sequestration Methane is a lower cost alternative to sugar … [Read more...] about Malonate Production via Bioengineered Methylomicrobium alcaliphilum 2022-098
Bio-based products
Non-oxidative Route for Glucose Metabolism in Pseudomonas putida 2020-110
APPLICATIONS OF TECHNOLOGY: Production of bio-based fuels, polymers, and specialty chemicals ADVANTAGES: Improved product titer, rate, and yields in comparison to biosynthesis using E. coli hosts Reduces CO2 production during aerobic/anaerobic bioprocesses Minimal metabolic engineering in comparison to E. coli hosts Ability to metabolize complex lignin … [Read more...] about Non-oxidative Route for Glucose Metabolism in Pseudomonas putida 2020-110
Genetically Modified Host Cells for Improved Polyketide Production 2022-152
APPLICATIONS OF TECHNOLOGY: High-value products using methylmalonyl-CoA as substrate: Erythromycin (antibiotic) and spinosyn (insecticide) Germicidin, which has significant inhibitory activity on hexokinase which is expressed at a high level in cancer cells Novel recyclable materials Flavors and fragrances Commodity or specialty chemicals ADVANTAGES: … [Read more...] about Genetically Modified Host Cells for Improved Polyketide Production 2022-152
Metabolic engineering of Issatchenkia orientalis for citramalate production used in PMMA Acrylic Glass 2023-056
APPLICATIONS OF TECHNOLOGY: Production of citramalate, a precursor for polymethyl methacrylate (PMMA) polymers. PMMA is used in electronic device screens, automotive plastics, glazing, building piping, and insulation ADVANTAGES: Increases the achievable carbon yields of select organic acids Consumes less energy and generates less toxic waste than current … [Read more...] about Metabolic engineering of Issatchenkia orientalis for citramalate production used in PMMA Acrylic Glass 2023-056
Expression Platform for Soluble Hydrogenase Production via Escherichia coli 2022-146
APPLICATIONS OF TECHNOLOGY: Renewable hydrocarbon production for biofuels such as biodiesel and ethanol E. coli that can use or produce H2 with its cellular processes, meaning H2 can now be used as a feedstock for biosynthesis. ADVANTAGES: Simplified and efficient expression system compared to traditional methods that use engineered Cupriavidus necator H16 … [Read more...] about Expression Platform for Soluble Hydrogenase Production via Escherichia coli 2022-146