APPLICATIONS OF TECHNOLOGY: Reduces complexity of genome Differentiates similar regions from mixed genomes, i.e., mixed cancer and normal cells from cancer tissue Enables haplotype genome sequencing Enables complex genome and metagenome assembly ADVANTAGES: Sequences and assembles a large number of long single DNA molecules without indexing during … [Read more...] about Long-range Barcode Labeled Sequencing for Efficient Genome and Metagenome Assembly IB-3019
Available Technologies
High Throughput Nanoparticle Delivery to the Cytosol of Living Cells IB-2849
APPLICATIONS OF TECHNOLOGY: Basic and applied research on intracellular processes Biological imaging Medical diagnostics Pharmaceutical development ADVANTAGES: Rapid cytosolic delivery within a few hours of incubation Mere picomolar concentrations of nanoparticles required for labeling Amenable to most nanoparticle formulations and cell/tissue … [Read more...] about High Throughput Nanoparticle Delivery to the Cytosol of Living Cells IB-2849
Simply Executed Nano-based Membrane Binding Sensor JIB-2649
APPLICATIONS OF TECHNOLOGY: Drug design, screening, and in vivo testing Clinical laboratory assays Biomedical research ADVANTAGES: Inexpensive implementation Can be achieved with a standard bench top spectrophotometer Scales up for high throughput Records real-time binding kinetics High signal-to-noise ratio Label-free detection ABSTRACT: Jay … [Read more...] about Simply Executed Nano-based Membrane Binding Sensor JIB-2649
Cell Surface Modification for Single Cell Analysis, Biosensing, and Tissue Engineering JIB-2703
APPLICATIONS OF TECHNOLOGY: Screening platforms for pharmaceuticals Biological production of biofuels Tissue engineering Cell-based biosensing ADVANTAGES: Faster and more biocompatible than existing methods Works for virtually all mammalian, plant, bacterial, and fungal cells Minimal to no effect on intracellular signaling pathways Enables … [Read more...] about Cell Surface Modification for Single Cell Analysis, Biosensing, and Tissue Engineering JIB-2703
Luminescent Nanocrystal Stress Gauge JIB-2727
APPLICATIONS OF TECHNOLOGY: Biomechanics Cancer research Polymer chemistry Optomechanical devices Failure analysis ADVANTAGES: Nanonewton sensitivity Nanoscale spatial resolution Fluorescent signal ABSTRACT: A team of Berkeley Lab scientists led by Paul Alivisatos and Charina Choi has developed a nanoscale stress sensor made of spider-like, … [Read more...] about Luminescent Nanocrystal Stress Gauge JIB-2727