ABSTRACT: Mina Bissell and colleagues at Berkeley Lab have developed therapeutic compositions and methods related to inhibition of FAM83A as well as methods of diagnosing cancer resistance to EGFR inhibitors. For details, see the issued U. S. Patent #9,303,088, available at www.uspto.gov. FOR MORE … [Read more...] about Detecting and Treating Breast Cancer Resistance to EGFR Inhibitors IB-2578
Available Technologies
Acid-Degradeable and Bioerodible Materials JIB-2595
APPLICATIONS OF TECHNOLOGY: Drug delivery, including controlled-release formulations Vaccine and immunotherapy Gene therapy Chemotherapy Sutures, scaffolds, and implantable bulk materials Diagnosis and imaging ADVANTAGES: Site-specific delivery, accurate therapeutic targeting Payload release or degradation rate can be tuned easily—from minutes to hours to … [Read more...] about Acid-Degradeable and Bioerodible Materials JIB-2595
ANXA9: A Therapeutic Target and Predictive Marker for Early Detection of Aggressive Breast Cancer JIB-2371
APPLICATIONS OF TECHNOLOGY: Breast cancer diagnosis Treatment of aggressive breast cancer and cancer resistant to chemotherapy ADVANTAGES: Prevents aggressive breast cancers from metastasizing Offers early detection of aggressive breast cancers May increase survival rates of breast cancer patients May improve response to chemotherapy … [Read more...] about ANXA9: A Therapeutic Target and Predictive Marker for Early Detection of Aggressive Breast Cancer JIB-2371
Methods and Proteins for Developing New Classes of Antibiotics IB-2346
APPLICATIONS OF TECHNOLOGY: Antibiotics for human and veterinary medicine Pesticides for crop management Food preservatives Genes engineered into probiotic bacteria ADVANTAGES: Overcomes antibiotic-resistance of bacteria Isolates new types of antimicrobial proteins that can be used for: Topical applications (ointment, cream, or lotion) that prevent … [Read more...] about Methods and Proteins for Developing New Classes of Antibiotics IB-2346
Protease-based Cancer Screening Using Nanoliter Samples IB-2240
APPLICATIONS OF TECHNOLOGY: Early stage screening of cancers via detection of proteases and proteolytic activity in fluid or biopsy samples Prostate cancer detection, and possibly the detection of other protease-related cancers such as breast, colon, kidney, skin, stomach, ovary, and lung cancer ADVANTAGES: Nanoliter sample volumes Reduces false positives for … [Read more...] about Protease-based Cancer Screening Using Nanoliter Samples IB-2240