APPLICATIONS OF TECHNOLOGY: High-value products using methylmalonyl-CoA as substrate: Erythromycin (antibiotic) and spinosyn (insecticide) Germicidin, which has significant inhibitory activity on hexokinase which is expressed at a high level in cancer cells Novel recyclable materials Flavors and fragrances Commodity or specialty chemicals ADVANTAGES: … [Read more...] about Genetically Modified Host Cells for Improved Polyketide Production 2022-152
Available Technologies
Metabolic engineering of Issatchenkia orientalis for citramalate production used in PMMA Acrylic Glass 2023-056
APPLICATIONS OF TECHNOLOGY: Production of citramalate, a precursor for polymethyl methacrylate (PMMA) polymers. PMMA is used in electronic device screens, automotive plastics, glazing, building piping, and insulation ADVANTAGES: Increases the achievable carbon yields of select organic acids Consumes less energy and generates less toxic waste than current … [Read more...] about Metabolic engineering of Issatchenkia orientalis for citramalate production used in PMMA Acrylic Glass 2023-056
Expression Platform for Soluble Hydrogenase Production via Escherichia coli 2022-146
APPLICATIONS OF TECHNOLOGY: Renewable hydrocarbon production for biofuels such as biodiesel and ethanol E. coli that can use or produce H2 with its cellular processes, meaning H2 can now be used as a feedstock for biosynthesis. ADVANTAGES: Simplified and efficient expression system compared to traditional methods that use engineered Cupriavidus necator H16 … [Read more...] about Expression Platform for Soluble Hydrogenase Production via Escherichia coli 2022-146
Energy Storage Technologies
Types of Technologies: Long Duration Storage Technologies Solid State Battery Technologies LLZO Based Solid State Battery Technologies Hydrogen Technologies Thermal Storage Technologies Lithium-Ion Battery Technologies Lithium-Sulfur Battery Technologies Recyclable Battery Technologies Long Duration Storage Technologies Longer Cycle … [Read more...] about Energy Storage Technologies
Chelating Ligands for Enhanced Radiolabeling and Therapeutic Potential 2023-119
APPLICATIONS OF TECHNOLOGY: Development of radiopharmaceuticals for cancer diagnosis and treatment Development of antibodies labeled with radionuclides BENEFITS: Simplified synthesis compared to other structures Faster radiolabeling at room temperature Formation of highly stable radiometal complexes Higher synthetic yields BACKGROUND: Thorium-227 … [Read more...] about Chelating Ligands for Enhanced Radiolabeling and Therapeutic Potential 2023-119