APPLICATIONS: Analysis of 3D cell culture model systems Oncology research and drug development Couples novel image analysis algorithms with 3D microscopy ADVANTAGES: End-to-end solution -- from assay to bioinformatics Enables 3D visualization and analysis of 3D spatial data Quantifies subcellular morphometric indices and corresponding molecular endpoints, on … [Read more...] about BioSig3D: Software for Integrated Imaging and Profiling of 3D Cell Culture Models 2013-177, 2014-024
Physical Sciences
Optimum Protein Solubility Screen IB-2005
APPLICATIONS OF TECHNOLOGY: Protein preparation for x-ray crystallography and NMR Protein purification kits and reagents Protein functional analysis ADVANTAGES: Rapidly identifies optimal conditions for protein solubility Works with very small amounts of protein (240 mg) Readily adaptable for high throughput processing; easily scalable to larger … [Read more...] about Optimum Protein Solubility Screen IB-2005
Human Blood Molecular Biodosimeter Panel for Distinguishing Radiation Exposure from Inflammation Stress IB-3304
APPLICATIONS OF TECHNOLOGY: Radiation oncology Medical triage Rapid response in cases of population exposure to ionizing radiation ADVANTAGES: Can be used in a small, handheld device Faster results Higher precision ABSTRACT: Berkeley Lab researchers Andrew Wyrobek and Antoine Snijders have identified a panel of gene and protein biomarkers that will help … [Read more...] about Human Blood Molecular Biodosimeter Panel for Distinguishing Radiation Exposure from Inflammation Stress IB-3304
MEA Chips for Integrated Microscopic Imaging and Liquid Chromatography Mass Spectrometry IB-3303
APPLICATIONS OF TECHNOLOGY: In-vitro diagnostics Electrospray ionization mass spectrometry (ESI-MS), chromatography, microscopy, single cell omics, microfluidics Biopharmaceutical R & D Lab-on-a-chip analysis Environmental monitoring ADVANTAGES: Integrated on-chip imaging and liquid chromatography functions Robust and scalable silicon … [Read more...] about MEA Chips for Integrated Microscopic Imaging and Liquid Chromatography Mass Spectrometry IB-3303
Genetic Barcodes for Cancer Prediction and Prognosis IB-2897
APPLICATIONS OF TECHNOLOGY: Cancer diagnostics and therapy ADVANTAGES: Fast, accurate, and affordable Improves tumor staging and patient stratification for most cancers ABSTRACT: Berkeley Lab researcher Heinz-Ulrich Weier has developed Genetic Barcodes, a fluorescent in situ hybridization (FISH)-based assay offering affordable diagnostics for the early … [Read more...] about Genetic Barcodes for Cancer Prediction and Prognosis IB-2897