APPLICATIONS OF TECHNOLOGY: In vitro diagnostics Biopharmaceutical R&D Systems biology laboratory research Single-cell “omics” Lab-on-a-chip analyses Food safety testing Environmental monitoring ADVANTAGES: Robust and scalable silicon fabrication technologies High-throughput multiplexing, i.e., processing multiple analytes sequentially … [Read more...] about Multinozzle Emitter Array (MEA) for On-chip Mass Spectrometry IB-2977
Physical Sciences
High Throughput Nanoparticle Delivery to the Cytosol of Living Cells IB-2849
APPLICATIONS OF TECHNOLOGY: Basic and applied research on intracellular processes Biological imaging Medical diagnostics Pharmaceutical development ADVANTAGES: Rapid cytosolic delivery within a few hours of incubation Mere picomolar concentrations of nanoparticles required for labeling Amenable to most nanoparticle formulations and cell/tissue … [Read more...] about High Throughput Nanoparticle Delivery to the Cytosol of Living Cells IB-2849
Luminescent Nanocrystal Stress Gauge JIB-2727
APPLICATIONS OF TECHNOLOGY: Biomechanics Cancer research Polymer chemistry Optomechanical devices Failure analysis ADVANTAGES: Nanonewton sensitivity Nanoscale spatial resolution Fluorescent signal ABSTRACT: A team of Berkeley Lab scientists led by Paul Alivisatos and Charina Choi has developed a nanoscale stress sensor made of spider-like, … [Read more...] about Luminescent Nanocrystal Stress Gauge JIB-2727
BioSig3D: Software for Integrated Imaging and Profiling of 3D Cell Culture Models 2013-177, 2014-024
APPLICATIONS: Analysis of 3D cell culture model systems Oncology research and drug development Couples novel image analysis algorithms with 3D microscopy ADVANTAGES: End-to-end solution -- from assay to bioinformatics Enables 3D visualization and analysis of 3D spatial data Quantifies subcellular morphometric indices and corresponding molecular endpoints, on … [Read more...] about BioSig3D: Software for Integrated Imaging and Profiling of 3D Cell Culture Models 2013-177, 2014-024
Optimum Protein Solubility Screen IB-2005
APPLICATIONS OF TECHNOLOGY: Protein preparation for x-ray crystallography and NMR Protein purification kits and reagents Protein functional analysis ADVANTAGES: Rapidly identifies optimal conditions for protein solubility Works with very small amounts of protein (240 mg) Readily adaptable for high throughput processing; easily scalable to larger … [Read more...] about Optimum Protein Solubility Screen IB-2005