APPLICATIONS OF TECHNOLOGY: Biobased fuel and chemical production ADVANTAGES: Addresses limits, due to toxicity of the final product, for microbial production levels of chemicals ABSTRACT: Researchers at Berkeley Lab’s Joint BioEnergy Institute (JBEI) have identified host cells with genetic modifications to an AcrB gene, or homolog, that result in improved … [Read more...] about Efflux Pump Variants to Improve Tolerance and Production of Alpha-Olefin 2013-181
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Predicting Metabolic Pathway Dynamics from Time Series Multiomics Data Using Machine Learning Techniques 2017-049
APPLICATIONS OF TECHNOLOGY: Genetic engineering ADVANTAGES: Outperforms kinetic models to predict pathway dynamics in bioengineered systems ABSTRACT: Hector Garcia Martin and Zac Costello of Berkeley Lab’s Joint BioEnergy Institute (JBEI) have determined that the combination of machine learning and abundant multiomics data (proteomics and metabolomics) can be … [Read more...] about Predicting Metabolic Pathway Dynamics from Time Series Multiomics Data Using Machine Learning Techniques 2017-049
High-Level Production of Fatty Alcohols from Engineered Yeast 2017-097
APPLICATIONS OF TECHNOLOGY: Industrial lubricants and surfactants Personal care products Biofuel production ADVANTAGES: Sustainable sourcing for fatty alcohols Highest titers and yields for fatty alcohols produced from cerevisiae yeast to date Allows for specific chemical modifications of fatty alcohols ABSTRACT: Joint BioEnergy Institute (JBEI) … [Read more...] about High-Level Production of Fatty Alcohols from Engineered Yeast 2017-097
Gold Nanoparticle Film for Nanostructure-Initiator Mass Spectrometry (NIMS) 2017-036
APPLICATIONS OF TECHNOLOGY: Foundational new approach to mass spectrometry that is compatible with microfluidics, for applications in Pharmaceuticals Biomanufacturing Diagnostics ADVANTAGES: Enables “yes/no” determinations in binding assays, also potentially with ability to identify what is being bound Simplifies wafer-level batch fabrication … [Read more...] about Gold Nanoparticle Film for Nanostructure-Initiator Mass Spectrometry (NIMS) 2017-036
Dominant Suppression of Xylan Biosynthesis Using IRX10 Catalytic Mutants 2017-008
APPLICATIONS OF TECHNOLOGY: Lignocellulosic biofuel production Animal forage crops Paper production ADVANTAGES: Rapid generation of crops with low xylan content Increased efficiency of biofuel conversion Applicable to a large variety of plant species ABSTRACT: A Joint BioEnergy Institute (JBEI) research team led by Henrik Vibe Scheller has … [Read more...] about Dominant Suppression of Xylan Biosynthesis Using IRX10 Catalytic Mutants 2017-008