Data Gathered using Berkeley Lab's Nanotoxicity Methodology (A) Numbers of genes whose expression levels changed after treatment with carbon nanomaterials at cytotoxic doses. (B-E) Venn diagrams comparing numbers of genes that showed expression changes. See the publication located at this link for more information on this image. APPLICATIONS: High throughput and … [Read more...] about Predictive Methodology and Tools for Nanotoxicology IB-2218b
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Nano-onion Therapy for Cancer Tumors IB-2218a
APPLICATIONS OF TECHNOLOGY: Response to Carbon Nano-onion Treatment Tumor therapy Infrared photosensitizing of cancer cells PET or MRI imaging reagents ADVANTAGES: A slow diffusion rate promises a longer lasting, localized, therapy Few significant side effects are anticipated More efficient than fullerenes in optothermal … [Read more...] about Nano-onion Therapy for Cancer Tumors IB-2218a
BioSig3D: Software for Integrated Imaging and Profiling of 3D Cell Culture Models 2013-177, 2014-024
APPLICATIONS: Analysis of 3D cell culture model systems Oncology research and drug development Couples novel image analysis algorithms with 3D microscopy ADVANTAGES: End-to-end solution -- from assay to bioinformatics Enables 3D visualization and analysis of 3D spatial data Quantifies subcellular morphometric indices and corresponding molecular endpoints, on … [Read more...] about BioSig3D: Software for Integrated Imaging and Profiling of 3D Cell Culture Models 2013-177, 2014-024
Combining Highly Sensitive Microarrays with Label-free Infrared Imaging 2014-015
ABSTRACT: From a research team led by Berkeley Lab's Hoi-Ying Holman: Archaea are usually minor components of a microbial community and dominated by a large and diverse bacterial population. In contrast, the SM1 Euryarchaeon dominates a sulfidic aquifer by forming subsurface biofilms that contain a very minor bacterial fraction (5%). These unique biofilms are delivered in … [Read more...] about Combining Highly Sensitive Microarrays with Label-free Infrared Imaging 2014-015
Long-term Growth of Finite Life Span Normal Human Epithelial Cells IB-2077
APPLICATIONS OF TECHNOLOGY: Examine carcinogenesis, aging, expression of genes, proteins and miRNA, signaling pathways, epigenetics, and genomic stability Develop quantitative assays for potentially pro or anti carcinogenic or aging agents, or toxic agents Generate transformed HMEC lines ADVANTAGES: Enables the creation of large standardized batches of normal … [Read more...] about Long-term Growth of Finite Life Span Normal Human Epithelial Cells IB-2077