ABSTRACT: From a research team led by Berkeley Lab's Hoi-Ying Holman: Archaea are usually minor components of a microbial community and dominated by a large and diverse bacterial population. In contrast, the SM1 Euryarchaeon dominates a sulfidic aquifer by forming subsurface biofilms that contain a very minor bacterial fraction (5%). These unique biofilms are delivered in … [Read more...] about Combining Highly Sensitive Microarrays with Label-free Infrared Imaging 2014-015
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Long-term Growth of Finite Life Span Normal Human Epithelial Cells IB-2077
APPLICATIONS OF TECHNOLOGY: Examine carcinogenesis, aging, expression of genes, proteins and miRNA, signaling pathways, epigenetics, and genomic stability Develop quantitative assays for potentially pro or anti carcinogenic or aging agents, or toxic agents Generate transformed HMEC lines ADVANTAGES: Enables the creation of large standardized batches of normal … [Read more...] about Long-term Growth of Finite Life Span Normal Human Epithelial Cells IB-2077
Aptamer for the Histidine Tag and an Improved Method for the Generation of High Affinity Aptamers IB-1929
APPLICATIONS OF TECHNOLOGY: Purification of five different His-tagged proteins expressed in E. coli using the Berkeley Lab His-tag aptamer magnetic beads (1a-5a) or commercially available … [Read more...] about Aptamer for the Histidine Tag and an Improved Method for the Generation of High Affinity Aptamers IB-1929
Optimum Protein Solubility Screen IB-2005
APPLICATIONS OF TECHNOLOGY: Protein preparation for x-ray crystallography and NMR Protein purification kits and reagents Protein functional analysis ADVANTAGES: Rapidly identifies optimal conditions for protein solubility Works with very small amounts of protein (240 mg) Readily adaptable for high throughput processing; easily scalable to larger … [Read more...] about Optimum Protein Solubility Screen IB-2005
Biomarker for Cell Senescence IB-1036
E.O. Lawrence Berkeley National Laboratory APPLICATIONS OF TECHNOLOGY: Screen compounds for effects on cell senescence, including high throughput applications Pre and post surgical tissue assay Cancer and aging research ADVANTAGES: This method provides a rapid, convenient and inexpensive basis to: Screen biological or pharmaceutical compounds that have … [Read more...] about Biomarker for Cell Senescence IB-1036