APPLICATIONS OF TECHNOLOGY: Personalized cancer treatment Clinical trials Development of secondary therapeutic combinations ADVANTAGES: Identifies molecular markers with greater specificity Distinctly models diverse drug response patterns Improves clinical outcomes Applies to multiple organ-specific cancers (breast, colon, pancreatic, ovarian, … [Read more...] about Identifying Biomarkers of Physiological Responses of Cancer Cells IB-2546
Cancer Therapeutics
High Selectivity Peptides for Cancer Therapy, Screening for Cancer Therapies, and Therapy Sensitization IB-2489
APPLICATIONS OF TECHNOLOGY: High-throughput screening for therapeutics that synergize with TIN2 complex disruption Sensitizing cancer cells to other therapeutic agents Therapy for multiple types of cancer exhibiting p53-negative cancer cells ADVANTAGES: Targets a subset of aggressive cancer cells by using TIN2-complex binding peptides Could be combined … [Read more...] about High Selectivity Peptides for Cancer Therapy, Screening for Cancer Therapies, and Therapy Sensitization IB-2489
Efficient, Reproducible Immortalization of Normal Human Mammary Epithelial Cells (HMECs) Using Pathologically Relevant Agents JIB- 2013-168
APPLICATIONS OF TECHNOLOGY: Testing potential therapeutics to prevent cancer progression to immortality and malignancy reverse immortalization in cancer cells Assays to identify agents that promote immortalization and malignancy Generation of immortal and malignant lines from any individual’s normal HMEC ADVANTAGES: Unique technology using … [Read more...] about Efficient, Reproducible Immortalization of Normal Human Mammary Epithelial Cells (HMECs) Using Pathologically Relevant Agents JIB- 2013-168
Breast Cancer Therapy and Potential Method for Enhancing Radiation Sensitivity via Inhibition of ß1 Integrin IB-1965
APPLICATIONS: Anti-tumor therapy Shows promise for increasing the radiation sensitivity of breast cancer cells ADVANTAGES: In vivo studies have demonstrated the effectiveness of ß1 integrin antibody for anti-tumor therapy In vitro studies show enhancement of radiation sensitivity The tissue environment responds to cancer in a consistent manner, providing a … [Read more...] about Breast Cancer Therapy and Potential Method for Enhancing Radiation Sensitivity via Inhibition of ß1 Integrin IB-1965
Microgels with Acid-Degradable Polymer Backbones for Delivering Bioactive Materials IB-1809b
APPLICATIONS OF TECHNOLOGY: Targeted delivery of protein and DNA-based therapeutics Vaccine delivery Cancer immunotherapy Site-specific treatment of inflammation Anti-sense therapy ADVANTAGES: Quickly degrades into small molecules under mildly acidic environments like those found in tumors, inflammatory tissues and lysosomes and phagolysosomes of antigen … [Read more...] about Microgels with Acid-Degradable Polymer Backbones for Delivering Bioactive Materials IB-1809b