APPLICATIONS OF TECHNOLOGY: Biofuels Commodity chemicals BENEFITS: Improves the isoprenol titer in the host Saccharomyces cerevisiae Creates a strong production system for isoprenol production BACKGROUND: Isoprenol (3-methyl-3-butene-1-ol) is a valuable biofuel and an important precursor of commodity chemicals. While a synthetic microbial system using … [Read more...] about Engineering S. cerevisiae to Produce Isoprenol for Sustainable Aviation Fuel and Chemicals 2020-086
Biofuels
Metal Chloride Deep Eutectic Solvents for Economical Biomass Fractionation 2019-092
APPLICATIONS OF TECHNOLOGY: Paper/pulping and cellulosic biofuel industry (i.e. delignification and fiber modification) BENEFITS: Capable of producing more than 90% of fermentable sugars Utilizes lignocellulosic biomass to its maximum potential Metal based DESs (mDESs) act as both solvent and catalyst BACKGROUND: Simultaneous conversion of … [Read more...] about Metal Chloride Deep Eutectic Solvents for Economical Biomass Fractionation 2019-092
Synthesis of Biofuels and Chemicals via Triketide Lactones, Engineered Through Polyketide Synthases (PKSs) 2020-057
APPLICATIONS OF TECHNOLOGY: Synthesis of biofuels, industrial chemicals, and specialty chemicals (e.g., valuable fragrances) BENEFITS: Promises to be more cost effective than chemical production Product could be labelled as “natural” in some jurisdictions Generation of lactones is of broad industrial utility Biosustainable production of molecules could … [Read more...] about Synthesis of Biofuels and Chemicals via Triketide Lactones, Engineered Through Polyketide Synthases (PKSs) 2020-057
Massive Scale Enzyme Screening Using Picoliter Droplet Array on Nanostructure-Initiator Mass Spectrometry 2019-097
APPLICATIONS OF TECHNOLOGY: Synthetic biology Biofuel production Drug development ADVANTAGES: Enables screening of hundreds of thousands of enzymes, which has not been feasible with any conventional method Allows investigation of multiple enzyme/substrate combinations as well as analysis of synergistic interactions and multi-step metabolic pathways … [Read more...] about Massive Scale Enzyme Screening Using Picoliter Droplet Array on Nanostructure-Initiator Mass Spectrometry 2019-097
Terminal deoxynucleotidyl transferase variants with enhanced thermostability 2019-015
APPLICATIONS: Molecular biology assays (TUNEL assay) Enzymatic de novo DNA synthesis with free dTNPs and polymerase-dNTP conjugates at elevated temperatures BENEFITS: Enhanced thermostability Increases the elongation rate for de novo DNA synthesis BACKGROUND: Terminal deoxynucleotidyl transferase (TdT) is used in several molecular biology methods. A … [Read more...] about Terminal deoxynucleotidyl transferase variants with enhanced thermostability 2019-015