APPLICATIONS OF TECHNOLOGY: Genetic modification of Saccharomyces cerevisiae for pentose fermentation and glucose-fructose isomerization Improved lignocellulose hydrolysate fermentation BENEFITS: Relative to current enzymes, this novel xylose isomerase shows: More than 2.5 times higher specific activity Almost 40% lower Km for D-xylose Higher activity … [Read more...] about A Novel D-Xylose Isomerase for Efficient Lignocellulosic Hydrolysate Fermentation 2019-132
Biofuels
Efficient Production of Oxidized Terpenes Via Enzyme Fusion Strategy 2019-108
APPLICATIONS OF TECHNOLOGY: Production of oxidized terpenes and of terpene-based bioproducts (e.g. fuel additives, fragrances, insecticides, pharmaceuticals) BENEFITS: Enables more efficient production of functionalized terpenes BACKGROUND: The functionalization of terpene hydrocarbons using cytochrome P450 enzymes could derive many useful compounds that … [Read more...] about Efficient Production of Oxidized Terpenes Via Enzyme Fusion Strategy 2019-108
Improving High Value Carotenoid Astaxanthin Production 2017-033
APPLICATIONS OF TECHNOLOGY: Human health and nutrition Biofuel feedstocks Food production ADVANTAGES: More economically viable means to produce microalgae Identifies specific genes required for astaxanthin antioxidant synthesis ABSTRACT: Researchers led by Melissa Roth of Howard Hughes Medical Institute and Krishna Niyogi of the Berkeley Lab have … [Read more...] about Improving High Value Carotenoid Astaxanthin Production 2017-033
Specific Reduction of Various Isoprenoid Precursors and Isoprenoids by Geranylgeranyl Reductases 2018-088
APPLICATIONS OF TECHNOLOGY: Bio-derived platform chemicals for use in Pharmaceuticals Cosmetics and fragrances Fuels ADVANTAGES: Lower cost, bio-based pathway to high value chemicals Reduction of intermediates within the terpene biosynthesis pathway Production of higher quantity of farnesyl acetate ABSTRACT: Researchers at Berkeley Lab’s Joint … [Read more...] about Specific Reduction of Various Isoprenoid Precursors and Isoprenoids by Geranylgeranyl Reductases 2018-088
Reduction of Cell Wall Methylation and Recalcitrance 2016-141
ABSTRACT: Plant biomass is a large source of fermentable sugars for the synthesis of bioproducts using engineered microbes. These sugars are stored as cell wall polymers, mainly cellulose and hemicellulose, and are embedded with lignin, which makes their enzymatic hydrolysis challenging. One of the strategies to reduce cell wall recalcitrance is the modification of lignin … [Read more...] about Reduction of Cell Wall Methylation and Recalcitrance 2016-141