APPLICATIONS OF TECHNOLOGY: High-value products using methylmalonyl-CoA as substrate: Erythromycin (antibiotic) and spinosyn (insecticide) Germicidin, which has significant inhibitory activity on hexokinase which is expressed at a high level in cancer cells Novel recyclable materials Flavors and fragrances Commodity or specialty chemicals ADVANTAGES: … [Read more...] about Genetically Modified Host Cells for Improved Polyketide Production 2022-152
Human Health/Precision Medicine
Chelating Ligands for Enhanced Radiolabeling and Therapeutic Potential 2023-119
APPLICATIONS OF TECHNOLOGY: Development of radiopharmaceuticals for cancer diagnosis and treatment Development of antibodies labeled with radionuclides BENEFITS: Simplified synthesis compared to other structures Faster radiolabeling at room temperature Formation of highly stable radiometal complexes Higher synthetic yields BACKGROUND: Thorium-227 … [Read more...] about Chelating Ligands for Enhanced Radiolabeling and Therapeutic Potential 2023-119
Imaging and Analysis Technologies
Novel Fluidic System for Accurate High Speed Atomic Force Microscopy (AFM) and Confocal/Super Resolution Systems 2021-020 This invention provides improved timing and concentration precision compared to current fluidic exchange designs. This tool is ideal for those conducting microscopy-based studies of reaction kinetics. Inventor: Paul Ashby. Contact: Sebastian Ainslie, … [Read more...] about Imaging and Analysis Technologies
High Throughput Characterization of Bacterial Promoters From Their Host Environments 2022-081
APPLICATIONS OF TECHNOLOGY: Health diagnoses (e.g., biomarker analysis) Environmental monitoring (e.g., soil, drinking water) Beauty and health (i.e. living therapeutics for skin conditions) Agriculture Drugs (i.e. search for biosensors associated with diseases) BENEFITS: Uses a DNA-barcoded promoter library and offers a rapid … [Read more...] about High Throughput Characterization of Bacterial Promoters From Their Host Environments 2022-081
Device & Methods for Diagnostic Spectroscopy of Biomaterials and Live Cells in Aqueous Environments 2020-064
APPLICATIONS OF TECHNOLOGY: Can be applied to different imaging systems including far-field spectromicroscopy and near-field nanospectroscopy Examples of suitable applications include: characterization of exosomes, vesicles, viruses, microbe-host cell interactions, enzymatic deconstruction of plant materials, biogeochemical processes, signaling during cell migrations … [Read more...] about Device & Methods for Diagnostic Spectroscopy of Biomaterials and Live Cells in Aqueous Environments 2020-064