APPLICATIONS OF TECHNOLOGY: Fluorescent protein labeling for Medical diagnostics Drug screening Biology research ADVANTAGES: Smaller size than green fluorescent protein (GFP) Long fluorescence lifetime Extends convenient tagging and fluorescence anisotropy (FA) study for larger sized proteins Can be used for FA-imaging of target proteins in living … [Read more...] about Genetically Encoded Sensors for Imaging Proteins and Their Complexes IB-3259
Human Health/Precision Medicine
MEA Chips for Integrated Microscopic Imaging and Liquid Chromatography Mass Spectrometry IB-3303
APPLICATIONS OF TECHNOLOGY: In-vitro diagnostics Electrospray ionization mass spectrometry (ESI-MS), chromatography, microscopy, single cell omics, microfluidics Biopharmaceutical R & D Lab-on-a-chip analysis Environmental monitoring ADVANTAGES: Integrated on-chip imaging and liquid chromatography functions Robust and scalable silicon … [Read more...] about MEA Chips for Integrated Microscopic Imaging and Liquid Chromatography Mass Spectrometry IB-3303
Genetic Barcodes for Cancer Prediction and Prognosis IB-2897
APPLICATIONS OF TECHNOLOGY: Cancer diagnostics and therapy ADVANTAGES: Fast, accurate, and affordable Improves tumor staging and patient stratification for most cancers ABSTRACT: Berkeley Lab researcher Heinz-Ulrich Weier has developed Genetic Barcodes, a fluorescent in situ hybridization (FISH)-based assay offering affordable diagnostics for the early … [Read more...] about Genetic Barcodes for Cancer Prediction and Prognosis IB-2897
Increased Glucose Metabolism is Oncogenic; Its Reversal May Be Therapeutic IB-2921
APPLICATIONS OF TECHNOLOGY: Cancer diagnostics Cancer therapeutics Cancer research ADVANTAGES: Provides markers correlated with increased metastases risk Provides for therapies that block or reverse cancer progression through adjusting glucose metabolism ABSTRACT: Berkeley Lab researchers led by Mina Bissell … [Read more...] about Increased Glucose Metabolism is Oncogenic; Its Reversal May Be Therapeutic IB-2921
Highly Stable 15nm Micelles for Drug Delivery and other Biomedical Applications JIB-2813, JIB-3230
APPLICATIONS OF TECHNOLOGY: Targeted drug delivery Gene therapy Vaccine development Imaging agents Cancer research ADVANTAGES: Long lasting – in vivo half-life 29.5 hours Tunable size and stability provide platform for drug formulation Low “cargo” leakage Deep penetration in tumor tissues – micelles in ~ 15nm range Self-assembling Efficient … [Read more...] about Highly Stable 15nm Micelles for Drug Delivery and other Biomedical Applications JIB-2813, JIB-3230