APPLICATIONS OF TECHNOLOGY: Targeted drug delivery Gene therapy Vaccine development Imaging agents Cancer research ADVANTAGES: Long lasting – in vivo half-life 29.5 hours Tunable size and stability provide platform for drug formulation Low “cargo” leakage Deep penetration in tumor tissues – micelles in ~ 15nm range Self-assembling Efficient … [Read more...] about Highly Stable 15nm Micelles for Drug Delivery and other Biomedical Applications JIB-2813, JIB-3230
Human Health/Precision Medicine
Assessing Endothelial Function with a Standard Blood Pressure Cuff IB-2772
APPLICATIONS OF TECHNOLOGY: Early identification of cardiovascular disease Endothelial function assessment ADVANTAGES: Easy to operate; no need for trained technician Facilitates regular patient testing and feedback More sensitive than conventional flow-mediated vasodilation (FMD) measurement Inexpensive to manufacture Fully automated test … [Read more...] about Assessing Endothelial Function with a Standard Blood Pressure Cuff IB-2772
Acid-Degradeable and Bioerodible Materials JIB-2595
APPLICATIONS OF TECHNOLOGY: Drug delivery, including controlled-release formulations Vaccine and immunotherapy Gene therapy Chemotherapy Sutures, scaffolds, and implantable bulk materials Diagnosis and imaging ADVANTAGES: Site-specific delivery, accurate therapeutic targeting Payload release or degradation rate can be tuned easily—from minutes to hours to … [Read more...] about Acid-Degradeable and Bioerodible Materials JIB-2595
Detecting and Treating Breast Cancer Resistance to EGFR Inhibitors IB-2578
ABSTRACT: Mina Bissell and colleagues at Berkeley Lab have developed therapeutic compositions and methods related to inhibition of FAM83A as well as methods of diagnosing cancer resistance to EGFR inhibitors. For details, see the issued U. S. Patent #9,303,088, available at www.uspto.gov. FOR MORE … [Read more...] about Detecting and Treating Breast Cancer Resistance to EGFR Inhibitors IB-2578
ANXA9: A Therapeutic Target and Predictive Marker for Early Detection of Aggressive Breast Cancer JIB-2371
APPLICATIONS OF TECHNOLOGY: Breast cancer diagnosis Treatment of aggressive breast cancer and cancer resistant to chemotherapy ADVANTAGES: Prevents aggressive breast cancers from metastasizing Offers early detection of aggressive breast cancers May increase survival rates of breast cancer patients May improve response to chemotherapy … [Read more...] about ANXA9: A Therapeutic Target and Predictive Marker for Early Detection of Aggressive Breast Cancer JIB-2371