APPLICATIONS OF TECHNOLOGY: Early stage screening of cancers via detection of proteases and proteolytic activity in fluid or biopsy samples Prostate cancer detection, and possibly the detection of other protease-related cancers such as breast, colon, kidney, skin, stomach, ovary, and lung cancer ADVANTAGES: Nanoliter sample volumes Reduces false positives for … [Read more...] about Protease-based Cancer Screening Using Nanoliter Samples IB-2240
Human Health/Precision Medicine
At-Home Test Kit and Lab Analysis for DNA Damage Assessment 2014-044
An at-home blood collection kit that immediately fixes blood cells’ biological activity enabling non-toxic sample shipment or storage without changes in specific DNA markers. Samples are treated and assessed in an automated, high-throughput, reproducible process yielding results that take each patient’s age, health status and exposure history into account. APPLICATIONS DNA … [Read more...] about At-Home Test Kit and Lab Analysis for DNA Damage Assessment 2014-044
Classification of Tumor Composition and Delineation of Cellular Regions via Dictionary and Sparse Coding IB- 2013-173
APPLICATIONS OF TECHNOLOGY: Digital histopathology Precision medicine in oncology Oncology drug development and R&D ADVANTAGES: Impervious to biological and technical batch variation Quantifies tumor composition via cell-by-cell profiling Measures cellular processes such as mitosis Extensible to a variety of other tumor types ABSTRACT: Berkeley … [Read more...] about Classification of Tumor Composition and Delineation of Cellular Regions via Dictionary and Sparse Coding IB- 2013-173
Efficient, Reproducible Immortalization of Normal Human Mammary Epithelial Cells (HMECs) Using Pathologically Relevant Agents JIB- 2013-168
APPLICATIONS OF TECHNOLOGY: Testing potential therapeutics to prevent cancer progression to immortality and malignancy reverse immortalization in cancer cells Assays to identify agents that promote immortalization and malignancy Generation of immortal and malignant lines from any individual’s normal HMEC ADVANTAGES: Unique technology using … [Read more...] about Efficient, Reproducible Immortalization of Normal Human Mammary Epithelial Cells (HMECs) Using Pathologically Relevant Agents JIB- 2013-168
Remineralization and Repair of Calcified Tissues using Biomimetic Polymer 2013-056
APPLICATIONS OF TECHNOLOGY: Preventive dentistry, e.g., toothpaste additive Regenerative, implant and cosmetic dentistry Periodontics and oral surgery Orthopedics Industrial processes requiring crystallization or amorphous precipitation ADVANTAGES: Minimally invasive route to restoring tooth structure Reduces dental health costs Biomimetic … [Read more...] about Remineralization and Repair of Calcified Tissues using Biomimetic Polymer 2013-056