APPLICATIONS OF TECHNOLOGY: Developing therapeutics for the radiosensitization of cancer cells Assessing the efficacy of cancer treatments Cancer drug screening and development Research on the in vivo activity of DNA-PK ADVANTAGES: Identifies two major DNA-PKcs autophosphorylation sites which are involved in DNA double strand break repair First technology to … [Read more...] about Antibodies for Monitoring and Phosphorylation Sites for Inhibiting DNA Double-Strand Break Repair IB-1807
Human Health/Precision Medicine
Microgels with Acid-Degradable Cross-Linkers for Vaccine and Cytoplasmic Drug Delivery IB-1809a
APPLICATIONS OF TECHNOLOGY: Targeted delivery of protein and DNA-based therapeutics Vaccine delivery Cancer immunotherapy Site-specific treatment of inflammation Anti-sense therapy ADVANTAGES: Delivers therapeutic material directly to the cytoplasm of cells Enhances immune response by facilitating cell surface antigen presentation Enables targeted … [Read more...] about Microgels with Acid-Degradable Cross-Linkers for Vaccine and Cytoplasmic Drug Delivery IB-1809a
Quantum Dot Based Cell Motility, Invasion, and Metastasis Assays IB-1755
APPLICATIONS OF TECHNOLOGY: Rapid method for assaying metastatic potential in biopsies Cancer drug development Research on cell motility ADVANTAGES: More photochemically robust than organic dyes Less labor intensive than the Boyden Chamber invasion assay Can be used with live cells no fixation/processing required Allows for real time variation of external … [Read more...] about Quantum Dot Based Cell Motility, Invasion, and Metastasis Assays IB-1755
Noninvasive Detection of Preclinical Cardiovascular Disease IB-1796
A subject's arm is shown positioned on the platform of the Berkeley Lab instrument. Artificial pulses are applied by the actuator and detected by an ultrasound probe. APPLICATIONS OF TECHNOLOGY: Detects cardiovascular disease (CVD) at the preclinical stage by measuring vasorelaxation Monitors the effects of statins and other drugs, vitamins, … [Read more...] about Noninvasive Detection of Preclinical Cardiovascular Disease IB-1796
Prognostic for Invasive and Metastatic Cancers IB-1637
APPLICATIONS OF TECHNOLOGY: Fig.1. Down regulation of Id-1 reduces metastatic spread. Prognostic marker for invasive and metastatic cancers Therapeutic target for the suppression of invasive and metastatic cancers ADVANTAGES: Provides a highly accurate marker for invasive and metastatic cancers Identifies Id-1, a key transcriptional regulator, as a target … [Read more...] about Prognostic for Invasive and Metastatic Cancers IB-1637