APPLICATIONS OF TECHNOLOGY: Preventive dentistry, e.g., toothpaste additive Regenerative, implant and cosmetic dentistry Periodontics and oral surgery Orthopedics Industrial processes requiring crystallization or amorphous precipitation ADVANTAGES: Minimally invasive route to restoring tooth structure Reduces dental health costs Biomimetic … [Read more...] about Remineralization and Repair of Calcified Tissues using Biomimetic Polymer 2013-056
Human Health/Precision Medicine
Breast Cancer Therapy and Potential Method for Enhancing Radiation Sensitivity via Inhibition of ß1 Integrin IB-1965
APPLICATIONS: Anti-tumor therapy Shows promise for increasing the radiation sensitivity of breast cancer cells ADVANTAGES: In vivo studies have demonstrated the effectiveness of ß1 integrin antibody for anti-tumor therapy In vitro studies show enhancement of radiation sensitivity The tissue environment responds to cancer in a consistent manner, providing a … [Read more...] about Breast Cancer Therapy and Potential Method for Enhancing Radiation Sensitivity via Inhibition of ß1 Integrin IB-1965
Synthetic Nano-Low Density Lipoprotein As a Targeted Drug Delivery Vehicle IB-1931
APPLICATIONS OF TECHNOLOGY: Natural LDL Berkeley Lab's Synthetic nLDL Drug delivery to tumors with increased LDL-cholesterol requirements and LDL receptor activity, including: brain, colon, prostrate, liver, lung, adrenal, hormone unresponsive breast, leukemia ADVANTAGES: Targets the LDL receptor for selective drug delivery and entry … [Read more...] about Synthetic Nano-Low Density Lipoprotein As a Targeted Drug Delivery Vehicle IB-1931
Early Identification of Vulnerable Atherosclerotic Plaques Using In Vivo MIR Spectroscopy and Imaging IB-1867
APPLICATION OF TECHNOLOGY: Predicting future recurrence of acute coronary syndromes In vitro mid-infrared (MIR) spectroscopy imaging of cells influencing atherosclerosis development In vivo characterization of atherosclerotic plaques Monitoring the effect of medical treatment on plaques ADVANTAGES: Only accurate method for the early identification of vulnerable … [Read more...] about Early Identification of Vulnerable Atherosclerotic Plaques Using In Vivo MIR Spectroscopy and Imaging IB-1867
Microgels with Acid-Degradable Polymer Backbones for Delivering Bioactive Materials IB-1809b
APPLICATIONS OF TECHNOLOGY: Targeted delivery of protein and DNA-based therapeutics Vaccine delivery Cancer immunotherapy Site-specific treatment of inflammation Anti-sense therapy ADVANTAGES: Quickly degrades into small molecules under mildly acidic environments like those found in tumors, inflammatory tissues and lysosomes and phagolysosomes of antigen … [Read more...] about Microgels with Acid-Degradable Polymer Backbones for Delivering Bioactive Materials IB-1809b