APPLICATIONS OF TECHNOLOGY: Combinatorial screening in Drug discovery and optimization Biomanufacturing Diagnostics ADVANTAGES: Enables faster testing of more diverse conditions / combinations Readily detects lanthanide/chelator complexes Maintains strong lanthanide binding and single-charge ionization Simplified … [Read more...] about Lanthanide-Chelator Barcode for Combinatorial Screening Applications 2016-121
Human Health/Precision Medicine
Dub-seq: Double Barcoded Shotgun Expression Library Sequencing 2015-160
APPLICATIONS OF TECHNOLOGY: Drug discovery and screening Functional genomics Synthetic biology Enzyme discovery ADVANTAGES: High throughput Scalable Less labor intensive and expensive than current approaches Enables gene function annotation ABSTRACT: Though current functional genomics technologies coupled with next generation sequencing have … [Read more...] about Dub-seq: Double Barcoded Shotgun Expression Library Sequencing 2015-160
A Universal Approach to Integrate and Express Pathways in a Broad Range of Bacteria 2016-024
APPLICATIONS OF TECHNOLOGY: Microbiome engineering for medicine, agriculture, biomanufacturing and renewable energy Pharmaceutical synthesis Commodity chemical and biofuel production Livestock research and development ADVANTAGES: Enables high-throughput, stable, accurate, efficient gene integration and expression of very large DNA constructs (e.g., … [Read more...] about A Universal Approach to Integrate and Express Pathways in a Broad Range of Bacteria 2016-024
Safe Preparation of Black Silicon Substrate for Nanostructure Initiator Mass Spectrometry (NIMS) 2015-122
APPLICATIONS: NIMS platform for analysis of biological molecules ADVANTAGES: More consistent, controlled NIMS chip production Does not require hydrofluoric acid Characteristics of the black silicon can be modified to alter NIMS sensitivity ABSTRACT: Trent Northen and other Berkeley Lab researchers have demonstrated a new technology for preparing black … [Read more...] about Safe Preparation of Black Silicon Substrate for Nanostructure Initiator Mass Spectrometry (NIMS) 2015-122
A Long Non-Coding RNA Expressed in Aggressive Cancer 2014-109
ABSTRACT Berkeley Lab researchers have developed technologies to evaluate levels of the long, non-coding RNA to assess the aggressiveness of a cancer and to modulate levels of the long non-coding RNA. This invention addresses the need to identify patients with potentially metastatic tumors versus non-metastatic tumors. For more details, see Published PCT patent … [Read more...] about A Long Non-Coding RNA Expressed in Aggressive Cancer 2014-109