APPLICATIONS OF TECHNOLOGY: Combined use with contemporary gene editing technologies for high precision gene expression Utilization of novel transcription factor effector domain activators to regulate gene expression in multiple hosts including plants and microbes BENEFITS: Method of metabolic and genome engineering using underutilized transcription factor … [Read more...] about Synthetic transcription factor systems for enhanced control of gene expression 2021-082
Microbiome
High Throughput Characterization of Bacterial Promoters From Their Host Environments 2022-081
APPLICATIONS OF TECHNOLOGY: Health diagnoses (e.g., biomarker analysis) Environmental monitoring (e.g., soil, drinking water) Beauty and health (i.e. living therapeutics for skin conditions) Agriculture Drugs (i.e. search for biosensors associated with diseases) BENEFITS: Uses a DNA-barcoded promoter library and offers a rapid … [Read more...] about High Throughput Characterization of Bacterial Promoters From Their Host Environments 2022-081
Engineered bacteria for enhanced crop production 2021-108
APPLICATIONS OF TECHNOLOGY: Dramatic enhancement of crop yields in agriculture applications though direct microbial application BENEFITS: Increased crop biomass (Arabidopsis) yield by 250-500% both in normal and drought conditions Enhanced durability and survivability in different environments Combined plant growth-promoting traits including growth promotion … [Read more...] about Engineered bacteria for enhanced crop production 2021-108
Microbiome Signature for Prognosis of Breast Cancer Patients 2021-175
APPLICATIONS OF TECHNOLOGY: Novel methods for predicting the overall prognosis of breast cancer patients BENEFITS: Integration of microbial abundance prognosis score (MAPS) into the nomogram significantly improves prognosis prediction BACKGROUND: Prognosis of breast cancer patients differs considerably and there is a need for identifying a … [Read more...] about Microbiome Signature for Prognosis of Breast Cancer Patients 2021-175
Gut Microbiome Engineering for the Heterologous Production of Antiviral Compounds 2019-085
APPLICATIONS OF TECHNOLOGY: Medical: Pharmaceuticals ADVANTAGES: Present strain is among the most robust constituents of the gut microbiome Obviates the need for exogenous iron-sulfur cluster producing genetic elements ABSTRACT: In 2018, Gizzi et al. demonstrated that the human gene Viperin can produce antiviral small molecules (ddhCTP) that act as a chain … [Read more...] about Gut Microbiome Engineering for the Heterologous Production of Antiviral Compounds 2019-085