APPLICATIONS OF TECHNOLOGY: Production of novel, unnatural bio-active molecules ADVANTAGES: Enables the uptake of artificial cofactor by a host cell and thereby the production of unnatural bio-actives TECHNOLOGY OVERVIEW: Numerous complex biomolecules have been produced by natural or engineered organisms, however, the structures that can be afforded are still … [Read more...] about Host cells and methods for producing unnatural terpenoids using a novel artificial metalloenzyme 2020-049
Biotechnology
Novel Enzymatic Process for the Production of Hydrogen Peroxide 2019-107
APPLICATIONS OF TECHNOLOGY: Paper and pulp industry Production of sodium percarbonate and sodium perborate for laundry detergent Production of propylene oxide Waste water treatment industry ADVANTAGES: Requires less capital-intensive equipment Cost competitive at scale ABSTRACT: Hydrogen peroxide is a commodity chemical produced at 4.5 billion … [Read more...] about Novel Enzymatic Process for the Production of Hydrogen Peroxide 2019-107
Marker-free Gene Insertion in Plants via CRISPR-Cas9 2019-055
APPLICATIONS OF TECHNOLOGY: Plant genome editing (e.g. targeted gene insertion) BENEFITS: This invention provides targeted gene insertion at pre-determined genomic safe harbors in plants at a much higher frequency than current methods. This provides a desirable alternative to random transgene insertion obtained through conventional methods. Obviation of the need … [Read more...] about Marker-free Gene Insertion in Plants via CRISPR-Cas9 2019-055
Efficient Production of Oxidized Terpenes Via Enzyme Fusion Strategy 2019-108
APPLICATIONS OF TECHNOLOGY: Production of oxidized terpenes and of terpene-based bioproducts (e.g. fuel additives, fragrances, insecticides, pharmaceuticals) BENEFITS: Enables more efficient production of functionalized terpenes BACKGROUND: The functionalization of terpene hydrocarbons using cytochrome P450 enzymes could derive many useful compounds that … [Read more...] about Efficient Production of Oxidized Terpenes Via Enzyme Fusion Strategy 2019-108
New Synthetic Transcription Factors and Promoters to Modulate Transgene Expression Strength 2019-100
APPLICATIONS: Agriculture Controlling gene expression in plants Modifying plants traits for the efficient production of food and other bio-based products BENEFITS: Creates a contributing effect of specific genetic elements in controlling gene expression Improvements in controlling and tuning gene expression Maximizes sequence diversity while tuning … [Read more...] about New Synthetic Transcription Factors and Promoters to Modulate Transgene Expression Strength 2019-100