APPLICATIONS OF TECHNOLOGY: Plant genome editing (e.g. targeted gene insertion) BENEFITS: This invention provides targeted gene insertion at pre-determined genomic safe harbors in plants at a much higher frequency than current methods. This provides a desirable alternative to random transgene insertion obtained through conventional methods. Obviation of the need … [Read more...] about Marker-free Gene Insertion in Plants via CRISPR-Cas9 2019-055
Biotechnology
Efficient Production of Oxidized Terpenes Via Enzyme Fusion Strategy 2019-108
APPLICATIONS OF TECHNOLOGY: Production of oxidized terpenes and of terpene-based bioproducts (e.g. fuel additives, fragrances, insecticides, pharmaceuticals) BENEFITS: Enables more efficient production of functionalized terpenes BACKGROUND: The functionalization of terpene hydrocarbons using cytochrome P450 enzymes could derive many useful compounds that … [Read more...] about Efficient Production of Oxidized Terpenes Via Enzyme Fusion Strategy 2019-108
New Synthetic Transcription Factors and Promoters to Modulate Transgene Expression Strength 2019-100
APPLICATIONS: Agriculture Controlling gene expression in plants Modifying plants traits for the efficient production of food and other bio-based products BENEFITS: Creates a contributing effect of specific genetic elements in controlling gene expression Improvements in controlling and tuning gene expression Maximizes sequence diversity while tuning … [Read more...] about New Synthetic Transcription Factors and Promoters to Modulate Transgene Expression Strength 2019-100
A System for Homogenous Editing of Mitochondrial Chromosomes 2017-153
APPLICATIONS OF TECHNOLOGY: Industrial biotechnology DNA mutation repair Genetics in organelles ADVANTAGES: Efficient, homoplasmic integrations in the mitochondrial genome Genetic change of the mtDNA without a selection marker BACKGROUND: Targeted genome engineering for mitochondria and other organelles has important implications in fungal, plant, … [Read more...] about A System for Homogenous Editing of Mitochondrial Chromosomes 2017-153
High Production Titers and Rates of Tetramethyl Pyrazine 2018-101
APPLICATIONS OF TECHNOLOGY: Food (coffee) flavoring Polymer/ resin component ADVANTAGES: While Corynebacterium glutamicum has been previously reported to produce alkyl pyrazines in mixture at low levels over a long cultivation period, the high production titers and rates of enriched tetramethyl pyrazine in glutamicum in … [Read more...] about High Production Titers and Rates of Tetramethyl Pyrazine 2018-101