APPLICATIONS OF TECHNOLOGY: Genome editing Genetic engineering Gene therapy Research tools (e.g., high-throughput screening of gene functions in cell lines and in vivo) Creation of transgenic animal models ADVANTAGES: Functions under different conditions than current CRISPR-Cas9 proteins (e.g, thermostable and enzymatically active in a wide temperature … [Read more...] about Thermostable RNA-Guided Endonucleases (GEOCAS9) 2017-117
Biotechnology
Enhancing Nitrogen Fertilizer Efficiency 2016-155
APPLICATIONS OF TECHNOLOGY: Agriculture ADVANTAGES: Reduced nitrogen loss to the atmosphere during fertilization More sustainable and economically profitable agricultural practices Improved agricultural efficiency ABSTRACT: Berkeley Lab’s Hans Carlson and Adam Deutschbauer have developed a technology to facilitate microbial nitrate reduction in nitrogen … [Read more...] about Enhancing Nitrogen Fertilizer Efficiency 2016-155
A Novel 12-Gene Prognostic Signature for Breast Cancer 2016-181
APPLICATIONS OF TECHNOLOGY: Targeted cancer therapies Prediction of relapse-free survival ADVANTAGES: Determines most effective treatment options for patient quality of life Standardizes breast cancer prognoses ABSTRACT: A Berkeley Lab research team led by Antoine Snijders has identified a 12-gene signature that can be used to predict relapse-free … [Read more...] about A Novel 12-Gene Prognostic Signature for Breast Cancer 2016-181
microNIMS for Enzyme Assay 2016-049
APPLICATIONS OF TECHNOLOGY: Industrial enzymes Biomass deconstruction for chemicals or fuel production ADVANTAGES: Sample preparation automated from the source Reduced reagent consumption Controlled transport Able to screen large numbers of mutants at small volumes using microfluidics ABSTRACT: Trent Northen and Joshua Heinemann of the Joint … [Read more...] about microNIMS for Enzyme Assay 2016-049
Optical-Cavity Phase Plate for Controllable, Stable Phase Shift in TEM and Cryo-EM Applications 2017-080
APPLICATIONS OF TECHNOLOGY: Biological research using high resolution cryogenic electron microscopy (cryo-EM) Hard-matter material characterization Other forms of research using transmission electron microscopy (TEM) ADVANTAGES: Ensures data of equally high quality for entire data collection period Equally useful for radiation-tolerant and … [Read more...] about Optical-Cavity Phase Plate for Controllable, Stable Phase Shift in TEM and Cryo-EM Applications 2017-080