APPLICATIONS OF TECHNOLOGY: Synthetic biology Genomics Gene characterization Drug discovery BENEFITS: Accelerates gene discovery and characterization toward practical applications Significantly reduces cost and turnaround time of DNA sequence synthesis Automatically detects and redesigns difficult sequences for DNA synthesis with higher success … [Read more...] about Build Optimization Software Tools (BOOST) for DNA Sequence Design 2016-107
Synthetic Biology Tools and Software
Engineering S. cerevisiae to Produce Isoprenol for Sustainable Aviation Fuel and Chemicals 2020-086
APPLICATIONS OF TECHNOLOGY: Biofuels Commodity chemicals BENEFITS: Improves the isoprenol titer in the host Saccharomyces cerevisiae Creates a strong production system for isoprenol production BACKGROUND: Isoprenol (3-methyl-3-butene-1-ol) is a valuable biofuel and an important precursor of commodity chemicals. While a synthetic microbial system using … [Read more...] about Engineering S. cerevisiae to Produce Isoprenol for Sustainable Aviation Fuel and Chemicals 2020-086
Marker-free Gene Insertion in Plants via CRISPR-Cas9 2019-055
APPLICATIONS OF TECHNOLOGY: Plant genome editing (e.g. targeted gene insertion) BENEFITS: This invention provides targeted gene insertion at pre-determined genomic safe harbors in plants at a much higher frequency than current methods. This provides a desirable alternative to random transgene insertion obtained through conventional methods. Obviation of the need … [Read more...] about Marker-free Gene Insertion in Plants via CRISPR-Cas9 2019-055
New Synthetic Transcription Factors and Promoters to Modulate Transgene Expression Strength 2019-100
APPLICATIONS: Agriculture Controlling gene expression in plants Modifying plants traits for the efficient production of food and other bio-based products BENEFITS: Creates a contributing effect of specific genetic elements in controlling gene expression Improvements in controlling and tuning gene expression Maximizes sequence diversity while tuning … [Read more...] about New Synthetic Transcription Factors and Promoters to Modulate Transgene Expression Strength 2019-100
A System for Homogenous Editing of Mitochondrial Chromosomes 2017-153
APPLICATIONS OF TECHNOLOGY: Industrial biotechnology DNA mutation repair Genetics in organelles ADVANTAGES: Efficient, homoplasmic integrations in the mitochondrial genome Genetic change of the mtDNA without a selection marker BACKGROUND: Targeted genome engineering for mitochondria and other organelles has important implications in fungal, plant, … [Read more...] about A System for Homogenous Editing of Mitochondrial Chromosomes 2017-153