APPLICATIONS OF TECHNOLOGY: Industrial biotechnology DNA mutation repair Genetics in organelles ADVANTAGES: Efficient, homoplasmic integrations in the mitochondrial genome Genetic change of the mtDNA without a selection marker BACKGROUND: Targeted genome engineering for mitochondria and other organelles has important implications in fungal, plant, … [Read more...] about A System for Homogenous Editing of Mitochondrial Chromosomes 2017-153
Synthetic Biology Tools and Software
Contactless Loading to a Microfluidic Chip 2019-078
APPLICATIONS OF TECHNOLOGY: Microfluidics Pico- and nano-liter dispensing devices Droplet microfluidics used for genomic and sequencing sample preparation and analysis ADVANTAGES: Minimizes waste Reduces costs Eliminates the additional steps for dispensing the desired sized droplets on chip Prevents the evaporation and merging of droplets Enables … [Read more...] about Contactless Loading to a Microfluidic Chip 2019-078
The CORAL Framework for FAIR Data Management and Analysis 2019-123
APPLICATIONS OF TECHNOLOGY: Moderately sized organizations or companies Multi-lab research collaborations ADVANTAGES: Low cost Ease of adding new data types Models different variations of the same conceptual data types Adheres to all four of the FAIR principles (see below) ABSTRACT: Researchers at Berkeley Lab have designed and prototyped a … [Read more...] about The CORAL Framework for FAIR Data Management and Analysis 2019-123
ART: A machine learning Automated Recommendation Tool for guiding synthetic biology 2020-011
APPLICATIONS: Companies performing synthetic biology/metabolic engineering ADVANTAGES: Demonstrated high predictive accuracy Shorter strain development times TECHNOLOGY OVERVIEW: Researchers at Berkeley Lab’s Joint BioEnergy Institute and the Agile BioFoundry have developed a tool that uses machine learning to make further advancements in the field … [Read more...] about ART: A machine learning Automated Recommendation Tool for guiding synthetic biology 2020-011
Novel fungal Autoinducible Expression System 2019-174
APPLICATIONS OF TECHNOLOGY: Biotech and pharmaceutical companies Commodity chemicals Potential to improve yield, titer, process efficiency and process economics for companies producing a variety of materials, chemicals and fuels in yeast cell factories ADVANTAGES: Useful in any media composition. Has value in both systems that produce high value compounds and … [Read more...] about Novel fungal Autoinducible Expression System 2019-174