APPLICATIONS OF TECHNOLOGY: Genome sequencing ABSTRACT: Increased sequencing of microbial genomes has revealed that prevailing prokaryotic species assignments can be inconsistent with whole genome information for a significant number of species. The long-standing need for a systematic and scalable species assignment technique can be met by the genome-wide Average … [Read more...] about ANIcalculator (Average Nucleotide Identity Calculator) 2014-127
Synthetic Biology Tools and Software
Thermostable RNA-Guided Endonucleases (GEOCAS9) 2017-117
APPLICATIONS OF TECHNOLOGY: Genome editing Genetic engineering Gene therapy Research tools (e.g., high-throughput screening of gene functions in cell lines and in vivo) Creation of transgenic animal models ADVANTAGES: Functions under different conditions than current CRISPR-Cas9 proteins (e.g, thermostable and enzymatically active in a wide temperature … [Read more...] about Thermostable RNA-Guided Endonucleases (GEOCAS9) 2017-117
microNIMS for Enzyme Assay 2016-049
APPLICATIONS OF TECHNOLOGY: Industrial enzymes Biomass deconstruction for chemicals or fuel production ADVANTAGES: Sample preparation automated from the source Reduced reagent consumption Controlled transport Able to screen large numbers of mutants at small volumes using microfluidics ABSTRACT: Trent Northen and Joshua Heinemann of the Joint … [Read more...] about microNIMS for Enzyme Assay 2016-049
ARGO: Peptide Barcoding for Genomic Discovery 2015-123
APPLICATIONS OF TECHNOLOGY: Biomanufacturing of enzymes Enzyme research ADVANTAGES: Rapid discovery of the function of genes Capable of multiplexing Ultra-high-throughput ABSTRACT: Researchers at Berkeley Lab led by Trent Northen have developed the ARGO (Assignment of the Reactions of Gene products in Organisms) platform, an efficient and scalable … [Read more...] about ARGO: Peptide Barcoding for Genomic Discovery 2015-123
Translation Control Tool for Plant Bioengineering 2013-166
APPLICATIONS OF TECHNOLOGY: Plant bioengineering ADVANTAGES: Fine-tunes RNA and protein expression Layering expression regulation Can be used for temporal and tissue specific expression repression ABSTRACT: A team of Joint BioEnergy Institute (JBEI) researchers led by Dominique Loqué has developed a new plant bioengineering system for improved precision … [Read more...] about Translation Control Tool for Plant Bioengineering 2013-166