APPLICATIONS OF TECHNOLOGY: Synthesis of biofuels, industrial chemicals, and specialty chemicals (e.g., valuable fragrances) BENEFITS: Promises to be more cost effective than chemical production Product could be labelled as “natural” in some jurisdictions Generation of lactones is of broad industrial utility Biosustainable production of molecules could … [Read more...] about Synthesis of Biofuels and Chemicals via Triketide Lactones, Engineered Through Polyketide Synthases (PKSs) 2020-057
Available Technologies
Massive Scale Enzyme Screening Using Picoliter Droplet Array on Nanostructure-Initiator Mass Spectrometry 2019-097
APPLICATIONS OF TECHNOLOGY: Synthetic biology Biofuel production Drug development ADVANTAGES: Enables screening of hundreds of thousands of enzymes, which has not been feasible with any conventional method Allows investigation of multiple enzyme/substrate combinations as well as analysis of synergistic interactions and multi-step metabolic pathways … [Read more...] about Massive Scale Enzyme Screening Using Picoliter Droplet Array on Nanostructure-Initiator Mass Spectrometry 2019-097
Terminal deoxynucleotidyl transferase variants with enhanced thermostability 2019-015
APPLICATIONS: Molecular biology assays (TUNEL assay) Enzymatic de novo DNA synthesis with free dTNPs and polymerase-dNTP conjugates at elevated temperatures BENEFITS: Enhanced thermostability Increases the elongation rate for de novo DNA synthesis BACKGROUND: Terminal deoxynucleotidyl transferase (TdT) is used in several molecular biology methods. A … [Read more...] about Terminal deoxynucleotidyl transferase variants with enhanced thermostability 2019-015
Layered/Rock Salt Intergrown Electrodes for Rechargeable Batteries 2018-142
APPLICATIONS OF TECHNOLOGY: Development of high-performance Li-ion cathodes BENEFITS: Enables a nearly zero-strain operation upon high-capacity cycling BACKGROUND: Rechargeable lithium-ion (Li-ion) batteries of high energy and power density are in increasing demand, with the market expected to reach $5B by 2024. There is a need for the cathode material to … [Read more...] about Layered/Rock Salt Intergrown Electrodes for Rechargeable Batteries 2018-142
A Novel D-Xylose Isomerase for Efficient Lignocellulosic Hydrolysate Fermentation 2019-132
APPLICATIONS OF TECHNOLOGY: Genetic modification of Saccharomyces cerevisiae for pentose fermentation and glucose-fructose isomerization Improved lignocellulose hydrolysate fermentation BENEFITS: Relative to current enzymes, this novel xylose isomerase shows: More than 2.5 times higher specific activity Almost 40% lower Km for D-xylose Higher activity … [Read more...] about A Novel D-Xylose Isomerase for Efficient Lignocellulosic Hydrolysate Fermentation 2019-132