APPLICATIONS OF TECHNOLOGY: Targeted delivery of protein and DNA-based therapeutics Vaccine delivery Cancer immunotherapy Site-specific treatment of inflammation Anti-sense therapy ADVANTAGES: Delivers therapeutic material directly to the cytoplasm of cells Enhances immune response by facilitating cell surface antigen presentation Enables targeted … [Read more...] about Microgels with Acid-Degradable Cross-Linkers for Vaccine and Cytoplasmic Drug Delivery IB-1809a
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Quantum Dot Based Cell Motility, Invasion, and Metastasis Assays IB-1755
APPLICATIONS OF TECHNOLOGY: Rapid method for assaying metastatic potential in biopsies Cancer drug development Research on cell motility ADVANTAGES: More photochemically robust than organic dyes Less labor intensive than the Boyden Chamber invasion assay Can be used with live cells no fixation/processing required Allows for real time variation of external … [Read more...] about Quantum Dot Based Cell Motility, Invasion, and Metastasis Assays IB-1755
Noninvasive Detection of Preclinical Cardiovascular Disease IB-1796
A subject's arm is shown positioned on the platform of the Berkeley Lab instrument. Artificial pulses are applied by the actuator and detected by an ultrasound probe. APPLICATIONS OF TECHNOLOGY: Detects cardiovascular disease (CVD) at the preclinical stage by measuring vasorelaxation Monitors the effects of statins and other drugs, vitamins, … [Read more...] about Noninvasive Detection of Preclinical Cardiovascular Disease IB-1796
Prognostic for Invasive and Metastatic Cancers IB-1637
APPLICATIONS OF TECHNOLOGY: Fig.1. Down regulation of Id-1 reduces metastatic spread. Prognostic marker for invasive and metastatic cancers Therapeutic target for the suppression of invasive and metastatic cancers ADVANTAGES: Provides a highly accurate marker for invasive and metastatic cancers Identifies Id-1, a key transcriptional regulator, as a target … [Read more...] about Prognostic for Invasive and Metastatic Cancers IB-1637
Synthetic Peptide that Causes Bundling of F-Actin in Vitro and in Situ IB-1571
APPLICATION OF TECHNOLOGY: Pharmaceutical to block cell division of rapidly growing cancer cells Pharmaceutical to block rapid spread of certain highly pathogenic bacteria and viruses Pharmaceutical to prevent metastasis Basic research tool to study the role of the actin cytoskeleton in various in vivo and in vitro processes ADVANTAGES: Synthetic … [Read more...] about Synthetic Peptide that Causes Bundling of F-Actin in Vitro and in Situ IB-1571