APPLICATIONS OF TECHNOLOGY: Drug design, screening, and in vivo testing Clinical laboratory assays Biomedical research ADVANTAGES: Inexpensive implementation Can be achieved with a standard bench top spectrophotometer Scales up for high throughput Records real-time binding kinetics High signal-to-noise ratio Label-free detection ABSTRACT: Jay … [Read more...] about Simply Executed Nano-based Membrane Binding Sensor JIB-2649
Research Tools
Cell Characterization by Phenotypic Analysis of Ligand Redistribution IB-2640
APPLICATIONS OF TECHNOLOGY: Drug design and testing Diagnosis and treatment of cancer and other diseases ADVANTAGES: Can be applied to living cells from biopsies Compatible with samples as small as a single cell May be scaled up to test multiple drugs simultaneously Analyzes phenotype rather than gene or protein expression Mimics and assesses … [Read more...] about Cell Characterization by Phenotypic Analysis of Ligand Redistribution IB-2640
High Throughput Purification and Identification of Cellular Protein Complexes JIB-2538
APPLICATIONS OF TECHNOLOGY: Biomedical research, drug design Biofuels Biodecontamination ADVANTAGES: More efficient than target affinity purification May be scaled up for high throughput Identifies multiple protein complexes simultaneously Low false positive and false negative rates ABSTRACT: Scientists at Berkeley Laboratory and the University of … [Read more...] about High Throughput Purification and Identification of Cellular Protein Complexes JIB-2538
A Cell Injection System Using Carbon Nanotubes IB-2323, IB-2333
APPLICATIONS OF TECHNOLOGY: Transfection of foreign molecular-scale cargoes into cells (e.g. DNA, RNA, polymers, dendrimers, nanoparticles, etc.) Insertion of probes into cells to observe physical and biochemical interactions. (e.g. quantum dots-probes) ADVANTAGES: Unlike microinjection, nanoneedle injection does not damage the cell membrane Overcomes other … [Read more...] about A Cell Injection System Using Carbon Nanotubes IB-2323, IB-2333
Predictive Methodology and Tools for Nanotoxicology IB-2218b
Data Gathered using Berkeley Lab's Nanotoxicity Methodology (A) Numbers of genes whose expression levels changed after treatment with carbon nanomaterials at cytotoxic doses. (B-E) Venn diagrams comparing numbers of genes that showed expression changes. See the publication located at this link for more information on this image. APPLICATIONS: High throughput and … [Read more...] about Predictive Methodology and Tools for Nanotoxicology IB-2218b