APPLICATIONS OF TECHNOLOGY: Multinozzle electrospray emitters for proteome-on-a-chip Mass spectroscopy of peptides and biomolecules with a wide range of weights Process for fabricating complex silicon-based bioanalytical tools ADVANTAGES: First monolithic interface between mass spectrometry and silicon based microfluidic technologies Can be massed … [Read more...] about Electrospray Emitters for Integrating Mass Spectrometry with Microfluidic Devices IB-2211
Research Tools
Long-term Growth of Finite Life Span Normal Human Epithelial Cells IB-2077
APPLICATIONS OF TECHNOLOGY: Examine carcinogenesis, aging, expression of genes, proteins and miRNA, signaling pathways, epigenetics, and genomic stability Develop quantitative assays for potentially pro or anti carcinogenic or aging agents, or toxic agents Generate transformed HMEC lines ADVANTAGES: Enables the creation of large standardized batches of normal … [Read more...] about Long-term Growth of Finite Life Span Normal Human Epithelial Cells IB-2077
Combining Highly Sensitive Microarrays with Label-free Infrared Imaging 2014-015
ABSTRACT: From a research team led by Berkeley Lab's Hoi-Ying Holman: Archaea are usually minor components of a microbial community and dominated by a large and diverse bacterial population. In contrast, the SM1 Euryarchaeon dominates a sulfidic aquifer by forming subsurface biofilms that contain a very minor bacterial fraction (5%). These unique biofilms are delivered in … [Read more...] about Combining Highly Sensitive Microarrays with Label-free Infrared Imaging 2014-015
BioSig3D: Software for Integrated Imaging and Profiling of 3D Cell Culture Models 2013-177, 2014-024
APPLICATIONS: Analysis of 3D cell culture model systems Oncology research and drug development Couples novel image analysis algorithms with 3D microscopy ADVANTAGES: End-to-end solution -- from assay to bioinformatics Enables 3D visualization and analysis of 3D spatial data Quantifies subcellular morphometric indices and corresponding molecular endpoints, on … [Read more...] about BioSig3D: Software for Integrated Imaging and Profiling of 3D Cell Culture Models 2013-177, 2014-024
Optimum Protein Solubility Screen IB-2005
APPLICATIONS OF TECHNOLOGY: Protein preparation for x-ray crystallography and NMR Protein purification kits and reagents Protein functional analysis ADVANTAGES: Rapidly identifies optimal conditions for protein solubility Works with very small amounts of protein (240 mg) Readily adaptable for high throughput processing; easily scalable to larger … [Read more...] about Optimum Protein Solubility Screen IB-2005