APPLICATIONS OF TECHNOLOGY: Biopharmaceuticals Cancer immunotherapy ADVANTAGES: Capable of interchanging antibodies, therefore, multi-functional Modular, available for use by human IgG1 and rabbit IgG antibodies Potential uses increase as more monoclonal antibody products developed ABSTRACT: Researchers at the Berkeley Lab have developed a … [Read more...] about Self-Assembling Protein Nanocage decorated with Antibodies (SAPNA) 2018-075
Human Health/Precision Medicine
In vitro Assembly, Adhering Cargo to Bacterial Microcompartment (BMC) Shells 2017-131, 2016-150
APPLICATIONS OF TECHNOLOGY: Enables health care, industrial and other commercial uses of protein-based bacterial organelles (bacterial microcompartments (BMCs)) ADVANTAGES: Modular system for 2- and 3-dimensional scaffolds/compartments Defined composition, atomic-resolution structure known Robust, programmable encapsulation or polyvalent display of multiple … [Read more...] about In vitro Assembly, Adhering Cargo to Bacterial Microcompartment (BMC) Shells 2017-131, 2016-150
Probiotics to Convey Resistance to Pesticide Poisoning 2017-083
APPLICATIONS OF TECHNOLOGY: Agriculture Pesticide resistance ADVANTAGES: Protects against toxic environmental chemicals Expands the metabolic potential of an individual’s microbiome for detoxification ABSTRACT: Berkeley Lab researchers led by Susan Celniker, Ben Brown, and Ken Wan have developed a technology to address pesticide sensitivity in … [Read more...] about Probiotics to Convey Resistance to Pesticide Poisoning 2017-083
Specific Reduction of Various Isoprenoid Precursors and Isoprenoids by Geranylgeranyl Reductases 2018-088
APPLICATIONS OF TECHNOLOGY: Bio-derived platform chemicals for use in Pharmaceuticals Cosmetics and fragrances Fuels ADVANTAGES: Lower cost, bio-based pathway to high value chemicals Reduction of intermediates within the terpene biosynthesis pathway Production of higher quantity of farnesyl acetate ABSTRACT: Researchers at Berkeley Lab’s Joint … [Read more...] about Specific Reduction of Various Isoprenoid Precursors and Isoprenoids by Geranylgeranyl Reductases 2018-088
PUMA: Ultrasensitive Detection of Biological and Chemical Agents 2017-054
APPLICATIONS OF TECHNOLOGY: • Point-of-care clinical diagnostics • Remote sensing of hazardous materials • Toxic gas leak detection • Physical incorporation into cell phones or small devices for remote detection, e.g., drones ADVANTAGES: • High specificity in analyte identification • Small in size for field portability • Low power requirement and cost • … [Read more...] about PUMA: Ultrasensitive Detection of Biological and Chemical Agents 2017-054