Novel Fluidic System for Accurate High Speed Atomic Force Microscopy (AFM) and Confocal/Super Resolution Systems 2021-020
This invention provides improved timing and concentration precision compared to current fluidic exchange designs. This tool is ideal for those conducting microscopy-based studies of reaction kinetics. Inventor: Paul Ashby. Contact: Sebastian Ainslie, SAinslie@lbl.gov
Spectroscopic Imaging and Analysis of Live Cells 2015-077
This invention is a tool for the measurement, visualization, and analysis of chemical dynamics in living cells or tissues for diagnostic pathology. Inventors: Keven Loutherback, Hoi-Ying Holman.
Contact: Jeremy Greeter, email@example.com
Gold Nanoparticle Film for Nanostructure-Initiator Mass Spectrometry (NIMS) 2017-036
This invention can detect small molecules, peptides, lipids, and enzyme activity. This tool can predictably fractionate complex samples to simplify the assay process for diagnostics, manufacturing, and pharmaceutical processes. Inventors: Todd Duncombe, Trent Northen.
Contact: Robin Johnston, RJohnston@lbl.gov
Contactless Loading to a Microfluidic Chip 2019-078
This invention minimizes waste, reduces cost, and streamlines loading of samples by size-matching the dispensed droplets to the microfluidic channels. Those looking for high throughput sample introduction for genomic and sequencing sample preparation and analysis will find this tool particularly useful. Inventors: Kosuke Iwai, William Gailard. Contact: Robin Johnston, RJohnston@lbl.gov
Parallel Droplet Manipulation and Digital Microfluidic Droplet Generation, Transport, Splitting, and Merging 2017-053
This invention enhances and streamlines drop manipulation, improves chip capabilities, and reduces manufacturing costs for increased experimental flexibility in synthetic biology and biological assay applications. Inventors: Philip Gach, Anup Singh. Contact: Robin Johnston, firstname.lastname@example.org
MicroNIMS for Enzyme Assay 2016-049
This invention can array large quantities of enzymes and substrate onto a defined grid to allow enzymatic characterization in addition to quantifying small molecule biomarkers from different biofluids. This tool addresses traditional incompatibilities between droplet and digital microfluidics and mass spectrometry-based detection. Inventors: Joshua Heinemann, Trent Northen. Contact: Robin Johnston, RJohnston@lbl.gov
Determining Ligninases Activities through Nanostructure Initiator Mass Spectrometry
This invention combines substrates for cellulase, hemicellulases and ligninases in a high throughput screening method to create assays that can simultaneously detect several enzyme activities. This is especially useful for capturing unknown or unexpected enzyme activities in cell cultures and environmental samples. Inventors: Kai Deng, Trent Northen. Contact: Robin Johnston, RJohnston@lbl.gov