APPLICATIONS OF TECHNOLOGY: Basic and applied research on intracellular processes Biological imaging Medical diagnostics Pharmaceutical development ADVANTAGES: Rapid cytosolic delivery within a few hours of incubation Mere picomolar concentrations of nanoparticles required for labeling Amenable to most nanoparticle formulations and cell/tissue … [Read more...] about High Throughput Nanoparticle Delivery to the Cytosol of Living Cells IB-2849
Diagnostics
Highly Sensitive Detector for Radiotracer Chromatography IB-2765
APPLICATIONS OF TECHNOLOGY: Analytical radiotracer high performance liquid chromatography (HPLC) Research of metabolic pathways for biofuels, drug development and medical diagnostics ADVANTAGES: One hundred times more sensitive than existing radiotracer HPLC Can be manufactured with existing hardware ABSTRACT: Scientists at Berkeley Lab have developed an … [Read more...] about Highly Sensitive Detector for Radiotracer Chromatography IB-2765
Cell Characterization by Phenotypic Analysis of Ligand Redistribution IB-2640
APPLICATIONS OF TECHNOLOGY: Drug design and testing Diagnosis and treatment of cancer and other diseases ADVANTAGES: Can be applied to living cells from biopsies Compatible with samples as small as a single cell May be scaled up to test multiple drugs simultaneously Analyzes phenotype rather than gene or protein expression Mimics and assesses … [Read more...] about Cell Characterization by Phenotypic Analysis of Ligand Redistribution IB-2640
Nano-onion Therapy for Cancer Tumors IB-2218a
APPLICATIONS OF TECHNOLOGY: Response to Carbon Nano-onion Treatment Tumor therapy Infrared photosensitizing of cancer cells PET or MRI imaging reagents ADVANTAGES: A slow diffusion rate promises a longer lasting, localized, therapy Few significant side effects are anticipated More efficient than fullerenes in optothermal … [Read more...] about Nano-onion Therapy for Cancer Tumors IB-2218a
Predictive Methodology and Tools for Nanotoxicology IB-2218b
Data Gathered using Berkeley Lab's Nanotoxicity Methodology (A) Numbers of genes whose expression levels changed after treatment with carbon nanomaterials at cytotoxic doses. (B-E) Venn diagrams comparing numbers of genes that showed expression changes. See the publication located at this link for more information on this image. APPLICATIONS: High throughput and … [Read more...] about Predictive Methodology and Tools for Nanotoxicology IB-2218b