APPLICATIONS OF TECHNOLOGY: Fluorescent protein labeling for Medical diagnostics Drug screening Biology research ADVANTAGES: Smaller size than green fluorescent protein (GFP) Long fluorescence lifetime Extends convenient tagging and fluorescence anisotropy (FA) study for larger sized proteins Can be used for FA-imaging of target proteins in living … [Read more...] about Genetically Encoded Sensors for Imaging Proteins and Their Complexes IB-3259
Diagnostics
Increased Glucose Metabolism is Oncogenic; Its Reversal May Be Therapeutic IB-2921
APPLICATIONS OF TECHNOLOGY: Cancer diagnostics Cancer therapeutics Cancer research ADVANTAGES: Provides markers correlated with increased metastases risk Provides for therapies that block or reverse cancer progression through adjusting glucose metabolism ABSTRACT: Berkeley Lab researchers led by Mina Bissell … [Read more...] about Increased Glucose Metabolism is Oncogenic; Its Reversal May Be Therapeutic IB-2921
Genetic Barcodes for Cancer Prediction and Prognosis IB-2897
APPLICATIONS OF TECHNOLOGY: Cancer diagnostics and therapy ADVANTAGES: Fast, accurate, and affordable Improves tumor staging and patient stratification for most cancers ABSTRACT: Berkeley Lab researcher Heinz-Ulrich Weier has developed Genetic Barcodes, a fluorescent in situ hybridization (FISH)-based assay offering affordable diagnostics for the early … [Read more...] about Genetic Barcodes for Cancer Prediction and Prognosis IB-2897
Assessing Endothelial Function with a Standard Blood Pressure Cuff IB-2772
APPLICATIONS OF TECHNOLOGY: Early identification of cardiovascular disease Endothelial function assessment ADVANTAGES: Easy to operate; no need for trained technician Facilitates regular patient testing and feedback More sensitive than conventional flow-mediated vasodilation (FMD) measurement Inexpensive to manufacture Fully automated test … [Read more...] about Assessing Endothelial Function with a Standard Blood Pressure Cuff IB-2772
Acid-Degradeable and Bioerodible Materials JIB-2595
APPLICATIONS OF TECHNOLOGY: Drug delivery, including controlled-release formulations Vaccine and immunotherapy Gene therapy Chemotherapy Sutures, scaffolds, and implantable bulk materials Diagnosis and imaging ADVANTAGES: Site-specific delivery, accurate therapeutic targeting Payload release or degradation rate can be tuned easily—from minutes to hours to … [Read more...] about Acid-Degradeable and Bioerodible Materials JIB-2595