APPLICATIONS OF TECHNOLOGY: Digital histopathology Precision medicine in oncology Oncology drug development and R&D ADVANTAGES: Impervious to biological and technical batch variation Quantifies tumor composition via cell-by-cell profiling Measures cellular processes such as mitosis Extensible to a variety of other tumor types ABSTRACT: Berkeley … [Read more...] about Classification of Tumor Composition and Delineation of Cellular Regions via Dictionary and Sparse Coding IB- 2013-173
Diagnostics
Early Identification of Vulnerable Atherosclerotic Plaques Using In Vivo MIR Spectroscopy and Imaging IB-1867
APPLICATION OF TECHNOLOGY: Predicting future recurrence of acute coronary syndromes In vitro mid-infrared (MIR) spectroscopy imaging of cells influencing atherosclerosis development In vivo characterization of atherosclerotic plaques Monitoring the effect of medical treatment on plaques ADVANTAGES: Only accurate method for the early identification of vulnerable … [Read more...] about Early Identification of Vulnerable Atherosclerotic Plaques Using In Vivo MIR Spectroscopy and Imaging IB-1867
Noninvasive Detection of Preclinical Cardiovascular Disease IB-1796
A subject's arm is shown positioned on the platform of the Berkeley Lab instrument. Artificial pulses are applied by the actuator and detected by an ultrasound probe. APPLICATIONS OF TECHNOLOGY: Detects cardiovascular disease (CVD) at the preclinical stage by measuring vasorelaxation Monitors the effects of statins and other drugs, vitamins, … [Read more...] about Noninvasive Detection of Preclinical Cardiovascular Disease IB-1796
Quantum Dot Based Cell Motility, Invasion, and Metastasis Assays IB-1755
APPLICATIONS OF TECHNOLOGY: Rapid method for assaying metastatic potential in biopsies Cancer drug development Research on cell motility ADVANTAGES: More photochemically robust than organic dyes Less labor intensive than the Boyden Chamber invasion assay Can be used with live cells no fixation/processing required Allows for real time variation of external … [Read more...] about Quantum Dot Based Cell Motility, Invasion, and Metastasis Assays IB-1755
Prognostic for Invasive and Metastatic Cancers IB-1637
APPLICATIONS OF TECHNOLOGY: Fig.1. Down regulation of Id-1 reduces metastatic spread. Prognostic marker for invasive and metastatic cancers Therapeutic target for the suppression of invasive and metastatic cancers ADVANTAGES: Provides a highly accurate marker for invasive and metastatic cancers Identifies Id-1, a key transcriptional regulator, as a target … [Read more...] about Prognostic for Invasive and Metastatic Cancers IB-1637