APPLICATIONS OF TECHNOLOGY: Genome editing Genetic engineering Gene therapy Research tools (e.g., high-throughput screening of gene functions in cell lines and in vivo) Creation of transgenic animal models ADVANTAGES: Functions under different conditions than current CRISPR-Cas9 proteins (e.g, thermostable and enzymatically active in a wide temperature … [Read more...] about Thermostable RNA-Guided Endonucleases (GEOCAS9) 2017-117
Research
ARGO: Peptide Barcoding for Genomic Discovery 2015-123
APPLICATIONS OF TECHNOLOGY: Biomanufacturing of enzymes Enzyme research ADVANTAGES: Rapid discovery of the function of genes Capable of multiplexing Ultra-high-throughput ABSTRACT: Researchers at Berkeley Lab led by Trent Northen have developed the ARGO (Assignment of the Reactions of Gene products in Organisms) platform, an efficient and scalable … [Read more...] about ARGO: Peptide Barcoding for Genomic Discovery 2015-123
Lanthanide-Chelator Barcode for Combinatorial Screening Applications 2016-121
APPLICATIONS OF TECHNOLOGY: Combinatorial screening in Drug discovery and optimization Biomanufacturing Diagnostics ADVANTAGES: Enables faster testing of more diverse conditions / combinations Readily detects lanthanide/chelator complexes Maintains strong lanthanide binding and single-charge ionization Simplified … [Read more...] about Lanthanide-Chelator Barcode for Combinatorial Screening Applications 2016-121
Dub-seq: Double Barcoded Shotgun Expression Library Sequencing 2015-160
APPLICATIONS OF TECHNOLOGY: Drug discovery and screening Functional genomics Synthetic biology Enzyme discovery ADVANTAGES: High throughput Scalable Less labor intensive and expensive than current approaches Enables gene function annotation ABSTRACT: Though current functional genomics technologies coupled with next generation sequencing have … [Read more...] about Dub-seq: Double Barcoded Shotgun Expression Library Sequencing 2015-160
Basal Media for Culturing Epithelial Cells 2015-009
APPLICATIONS: Growing primary human epithelial cells for Pharmaceutical development Toxicology Biotechnology research ADVANTAGES: Regular and consistent formulation Superior growth for 1/12 of the price Up to 60 population doublings Can sustain long term cultures ABSTRACT: Researchers at Berkeley Lab have developed a low cost technology for growing … [Read more...] about Basal Media for Culturing Epithelial Cells 2015-009