APPLICATIONS OF TECHNOLOGY: Natural LDL Berkeley Lab's Synthetic nLDL Drug delivery to tumors with increased LDL-cholesterol requirements and LDL receptor activity, including: brain, colon, prostrate, liver, lung, adrenal, hormone unresponsive breast, leukemia ADVANTAGES: Targets the LDL receptor for selective drug delivery and entry … [Read more...] about Synthetic Nano-Low Density Lipoprotein As a Targeted Drug Delivery Vehicle IB-1931
Diagnostics and Therapeutics
Early Identification of Vulnerable Atherosclerotic Plaques Using In Vivo MIR Spectroscopy and Imaging IB-1867
APPLICATION OF TECHNOLOGY: Predicting future recurrence of acute coronary syndromes In vitro mid-infrared (MIR) spectroscopy imaging of cells influencing atherosclerosis development In vivo characterization of atherosclerotic plaques Monitoring the effect of medical treatment on plaques ADVANTAGES: Only accurate method for the early identification of vulnerable … [Read more...] about Early Identification of Vulnerable Atherosclerotic Plaques Using In Vivo MIR Spectroscopy and Imaging IB-1867
Noninvasive Detection of Preclinical Cardiovascular Disease IB-1796
A subject's arm is shown positioned on the platform of the Berkeley Lab instrument. Artificial pulses are applied by the actuator and detected by an ultrasound probe. APPLICATIONS OF TECHNOLOGY: Detects cardiovascular disease (CVD) at the preclinical stage by measuring vasorelaxation Monitors the effects of statins and other drugs, vitamins, … [Read more...] about Noninvasive Detection of Preclinical Cardiovascular Disease IB-1796
Prognostic for Invasive and Metastatic Cancers IB-1637
APPLICATIONS OF TECHNOLOGY: Fig.1. Down regulation of Id-1 reduces metastatic spread. Prognostic marker for invasive and metastatic cancers Therapeutic target for the suppression of invasive and metastatic cancers ADVANTAGES: Provides a highly accurate marker for invasive and metastatic cancers Identifies Id-1, a key transcriptional regulator, as a target … [Read more...] about Prognostic for Invasive and Metastatic Cancers IB-1637
Polymerized Nanoparticle Therapeutics IB-1056
Ernest Orlando Lawrence Berkeley National Laboratory APPLICATIONS OF TECHNOLOGY: Drug delivery Therapeutic potential for inflammatory … [Read more...] about Polymerized Nanoparticle Therapeutics IB-1056