ABSTRACT: Mina Bissell and colleagues at Berkeley Lab have developed therapeutic compositions and methods related to inhibition of FAM83A as well as methods of diagnosing cancer resistance to EGFR inhibitors. For details, see the issued U. S. Patent #9,303,088, available at www.uspto.gov. FOR MORE … [Read more...] about Detecting and Treating Breast Cancer Resistance to EGFR Inhibitors IB-2578
Therapeutics
Methods and Proteins for Developing New Classes of Antibiotics IB-2346
APPLICATIONS OF TECHNOLOGY: Antibiotics for human and veterinary medicine Pesticides for crop management Food preservatives Genes engineered into probiotic bacteria ADVANTAGES: Overcomes antibiotic-resistance of bacteria Isolates new types of antimicrobial proteins that can be used for: Topical applications (ointment, cream, or lotion) that prevent … [Read more...] about Methods and Proteins for Developing New Classes of Antibiotics IB-2346
Efficient, Reproducible Immortalization of Normal Human Mammary Epithelial Cells (HMECs) Using Pathologically Relevant Agents JIB- 2013-168
APPLICATIONS OF TECHNOLOGY: Testing potential therapeutics to prevent cancer progression to immortality and malignancy reverse immortalization in cancer cells Assays to identify agents that promote immortalization and malignancy Generation of immortal and malignant lines from any individual’s normal HMEC ADVANTAGES: Unique technology using … [Read more...] about Efficient, Reproducible Immortalization of Normal Human Mammary Epithelial Cells (HMECs) Using Pathologically Relevant Agents JIB- 2013-168
Remineralization and Repair of Calcified Tissues using Biomimetic Polymer 2013-056
APPLICATIONS OF TECHNOLOGY: Preventive dentistry, e.g., toothpaste additive Regenerative, implant and cosmetic dentistry Periodontics and oral surgery Orthopedics Industrial processes requiring crystallization or amorphous precipitation ADVANTAGES: Minimally invasive route to restoring tooth structure Reduces dental health costs Biomimetic … [Read more...] about Remineralization and Repair of Calcified Tissues using Biomimetic Polymer 2013-056
Breast Cancer Therapy and Potential Method for Enhancing Radiation Sensitivity via Inhibition of ß1 Integrin IB-1965
APPLICATIONS: Anti-tumor therapy Shows promise for increasing the radiation sensitivity of breast cancer cells ADVANTAGES: In vivo studies have demonstrated the effectiveness of ß1 integrin antibody for anti-tumor therapy In vitro studies show enhancement of radiation sensitivity The tissue environment responds to cancer in a consistent manner, providing a … [Read more...] about Breast Cancer Therapy and Potential Method for Enhancing Radiation Sensitivity via Inhibition of ß1 Integrin IB-1965