APPLICATIONS OF TECHNOLOGY: Rapid method for assaying metastatic potential in biopsies Cancer drug development Research on cell motility ADVANTAGES: More photochemically robust than organic dyes Less labor intensive than the Boyden Chamber invasion assay Can be used with live cells – no fixation/processing required Allows for real time variation of external … [Read more...] about Quantum Dot Based Cell Motility, Invasion, and Metastasis Assays IB-1755
Therapeutics
Prognostic for Invasive and Metastatic Cancers IB-1637
APPLICATIONS OF TECHNOLOGY: Fig.1. Down regulation of Id-1 reduces metastatic spread. Prognostic marker for invasive and metastatic cancers Therapeutic target for the suppression of invasive and metastatic cancers ADVANTAGES: Provides a highly accurate marker for invasive and metastatic cancers Identifies Id-1, a key transcriptional regulator, as a target … [Read more...] about Prognostic for Invasive and Metastatic Cancers IB-1637
Mouse Model for Common Genetic Risk Factor for Cardiovascular Disease IB-2789
APPLICATIONS OF TECHNOLOGY: Research of cardiovascular disease treatment and prevention methods ADVANTAGES: Provides new targets for coronary artery disease (CAD) and cancer drugs Enables new research avenues in Coronary artery disease and cancer Cdkn2a/b and other cyclin-dependent kinase inhibitors Disease mechanisms involving non-coding … [Read more...] about Mouse Model for Common Genetic Risk Factor for Cardiovascular Disease IB-2789
Phototriggerable Microcapsules JIB-2778
2010 R&D100 Award Winner APPLICATIONS OF TECHNOLOGY: Remote drug delivery inside the body Less invasive surgeries UV-resistant plastics and composites Self-healing plastics, polymers, paint, or concrete Master template preparation for offset printing Cosmetic and skin care items ADVANTAGES: Reaction speed, timing, and location can be … [Read more...] about Phototriggerable Microcapsules JIB-2778
Microbial Synthesis of Hydroxytyrosol and Other Aromatic Amino Acid Derivatives EJIB-2939
APPLICATIONS OF TECHNOLOGY: Microbial production of Antioxidants, e.g., hydroxytyrosol Supplements, e.g., melatonin Medications, e.g., L-DOPA ADVANTAGES: Inexpensive, consistent production with minimal impurities Independent of olive crop production and expensive chemical synthesis that produces toxic waste Modifiable to produce desired substances … [Read more...] about Microbial Synthesis of Hydroxytyrosol and Other Aromatic Amino Acid Derivatives EJIB-2939