APPLICATIONS OF TECHNOLOGY: Natural LDL Berkeley Lab's Synthetic nLDL Drug delivery to tumors with increased LDL-cholesterol requirements and LDL receptor activity, including: brain, colon, prostrate, liver, lung, adrenal, hormone unresponsive breast, leukemia ADVANTAGES: Targets the LDL receptor for selective drug delivery and entry … [Read more...] about Synthetic Nano-Low Density Lipoprotein As a Targeted Drug Delivery Vehicle IB-1931
Therapeutics
Microgels with Acid-Degradable Polymer Backbones for Delivering Bioactive Materials IB-1809b
APPLICATIONS OF TECHNOLOGY: Targeted delivery of protein and DNA-based therapeutics Vaccine delivery Cancer immunotherapy Site-specific treatment of inflammation Anti-sense therapy ADVANTAGES: Quickly degrades into small molecules under mildly acidic environments like those found in tumors, inflammatory tissues and lysosomes and phagolysosomes of antigen … [Read more...] about Microgels with Acid-Degradable Polymer Backbones for Delivering Bioactive Materials IB-1809b
Microgels with Acid-Degradable Cross-Linkers for Vaccine and Cytoplasmic Drug Delivery IB-1809a
APPLICATIONS OF TECHNOLOGY: Targeted delivery of protein and DNA-based therapeutics Vaccine delivery Cancer immunotherapy Site-specific treatment of inflammation Anti-sense therapy ADVANTAGES: Delivers therapeutic material directly to the cytoplasm of cells Enhances immune response by facilitating cell surface antigen presentation Enables targeted … [Read more...] about Microgels with Acid-Degradable Cross-Linkers for Vaccine and Cytoplasmic Drug Delivery IB-1809a
Antibodies for Monitoring and Phosphorylation Sites for Inhibiting DNA Double-Strand Break Repair IB-1807
APPLICATIONS OF TECHNOLOGY: Developing therapeutics for the radiosensitization of cancer cells Assessing the efficacy of cancer treatments Cancer drug screening and development Research on the in vivo activity of DNA-PK ADVANTAGES: Identifies two major DNA-PKcs autophosphorylation sites which are involved in DNA double strand break repair First technology to … [Read more...] about Antibodies for Monitoring and Phosphorylation Sites for Inhibiting DNA Double-Strand Break Repair IB-1807
Noninvasive Detection of Preclinical Cardiovascular Disease IB-1796
A subject's arm is shown positioned on the platform of the Berkeley Lab instrument. Artificial pulses are applied by the actuator and detected by an ultrasound probe. APPLICATIONS OF TECHNOLOGY: Detects cardiovascular disease (CVD) at the preclinical stage by measuring vasorelaxation Monitors the effects of statins and other drugs, vitamins, … [Read more...] about Noninvasive Detection of Preclinical Cardiovascular Disease IB-1796