APPLICATIONS OF TECHNOLOGY: Targeted drug delivery Gene therapy Vaccine development Imaging agents Cancer research ADVANTAGES: Long lasting – in vivo half-life 29.5 hours Tunable size and stability provide platform for drug formulation Low “cargo” leakage Deep penetration in tumor tissues – micelles in ~ 15nm range Self-assembling Efficient … [Read more...] about Highly Stable 15nm Micelles for Drug Delivery and other Biomedical Applications JIB-2813, JIB-3230
Therapeutics
Detecting and Treating Breast Cancer Resistance to EGFR Inhibitors IB-2578
ABSTRACT: Mina Bissell and colleagues at Berkeley Lab have developed therapeutic compositions and methods related to inhibition of FAM83A as well as methods of diagnosing cancer resistance to EGFR inhibitors. For details, see the issued U. S. Patent #9,303,088, available at www.uspto.gov. FOR MORE … [Read more...] about Detecting and Treating Breast Cancer Resistance to EGFR Inhibitors IB-2578
Acid-Degradeable and Bioerodible Materials JIB-2595
APPLICATIONS OF TECHNOLOGY: Drug delivery, including controlled-release formulations Vaccine and immunotherapy Gene therapy Chemotherapy Sutures, scaffolds, and implantable bulk materials Diagnosis and imaging ADVANTAGES: Site-specific delivery, accurate therapeutic targeting Payload release or degradation rate can be tuned easily—from minutes to hours to … [Read more...] about Acid-Degradeable and Bioerodible Materials JIB-2595
Methods and Proteins for Developing New Classes of Antibiotics IB-2346
APPLICATIONS OF TECHNOLOGY: Antibiotics for human and veterinary medicine Pesticides for crop management Food preservatives Genes engineered into probiotic bacteria ADVANTAGES: Overcomes antibiotic-resistance of bacteria Isolates new types of antimicrobial proteins that can be used for: Topical applications (ointment, cream, or lotion) that prevent … [Read more...] about Methods and Proteins for Developing New Classes of Antibiotics IB-2346
Efficient, Reproducible Immortalization of Normal Human Mammary Epithelial Cells (HMECs) Using Pathologically Relevant Agents JIB- 2013-168
APPLICATIONS OF TECHNOLOGY: Testing potential therapeutics to prevent cancer progression to immortality and malignancy reverse immortalization in cancer cells Assays to identify agents that promote immortalization and malignancy Generation of immortal and malignant lines from any individual’s normal HMEC ADVANTAGES: Unique technology using … [Read more...] about Efficient, Reproducible Immortalization of Normal Human Mammary Epithelial Cells (HMECs) Using Pathologically Relevant Agents JIB- 2013-168