APPLICATIONS OF TECHNOLOGY: Developing therapeutics for the radiosensitization of cancer cells Assessing the efficacy of cancer treatments Cancer drug screening and development Research on the in vivo activity of DNA-PK ADVANTAGES: Identifies two major DNA-PKcs autophosphorylation sites which are involved in DNA double strand break repair First technology to … [Read more...] about Antibodies for Monitoring and Phosphorylation Sites for Inhibiting DNA Double-Strand Break Repair IB-1807
Therapeutics
Noninvasive Detection of Preclinical Cardiovascular Disease IB-1796
A subject's arm is shown positioned on the platform of the Berkeley Lab instrument. Artificial pulses are applied by the actuator and detected by an ultrasound probe. APPLICATIONS OF TECHNOLOGY: Detects cardiovascular disease (CVD) at the preclinical stage by measuring vasorelaxation Monitors the effects of statins and other drugs, vitamins, … [Read more...] about Noninvasive Detection of Preclinical Cardiovascular Disease IB-1796
Quantum Dot Based Cell Motility, Invasion, and Metastasis Assays IB-1755
APPLICATIONS OF TECHNOLOGY: Rapid method for assaying metastatic potential in biopsies Cancer drug development Research on cell motility ADVANTAGES: More photochemically robust than organic dyes Less labor intensive than the Boyden Chamber invasion assay Can be used with live cells no fixation/processing required Allows for real time variation of external … [Read more...] about Quantum Dot Based Cell Motility, Invasion, and Metastasis Assays IB-1755
Prognostic for Invasive and Metastatic Cancers IB-1637
APPLICATIONS OF TECHNOLOGY: Fig.1. Down regulation of Id-1 reduces metastatic spread. Prognostic marker for invasive and metastatic cancers Therapeutic target for the suppression of invasive and metastatic cancers ADVANTAGES: Provides a highly accurate marker for invasive and metastatic cancers Identifies Id-1, a key transcriptional regulator, as a target … [Read more...] about Prognostic for Invasive and Metastatic Cancers IB-1637
Mouse Model for Common Genetic Risk Factor for Cardiovascular Disease IB-2789
APPLICATIONS OF TECHNOLOGY: Research of cardiovascular disease treatment and prevention methods ADVANTAGES: Provides new targets for coronary artery disease (CAD) and cancer drugs Enables new research avenues in Coronary artery disease and cancer Cdkn2a/b and other cyclin-dependent kinase inhibitors Disease mechanisms involving non-coding … [Read more...] about Mouse Model for Common Genetic Risk Factor for Cardiovascular Disease IB-2789